Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.32 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.32 |
| ▸ | RPS17 | P08708 | 1/20 | 0.32 |
| ▸ | RPSA | P08865 | 1/20 | 0.32 |
| ▸ | RPS2 | P15880 | 1/20 | 0.32 |
| ▸ | RPL35A | P18077 | 1/20 | 0.32 |
| ▸ | RPL7 | P18124 | 1/20 | 0.32 |
| ▸ | RPL17 | P18621 | 1/20 | 0.32 |
| ▸ | RPS4Y1 | P22090 | 1/20 | 0.32 |
| ▸ | RPS3 | P23396 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21392050 | 0.83 | CACNA1B (0.35) | CACNA1BBRD4APLNRSMN1; SMN2ALDH1A1 | |
| SCHEMBL21392159 | 0.81 | SLC2A1 (0.32) | CACNA1BBRD4SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL21392168 | 0.78 | APLNR (0.33) | APLNRSMN1; SMN2ALDH1A1HTTTRPM8 | |
| SCHEMBL21391987 | 0.73 | CLK4 (0.36) | SMN1; SMN2ALDH1A1HTTLMNAKCNH2 | |
| SCHEMBL21392246 | 0.70 | APLNR (0.35) | APLNRSMN1; SMN2ALDH1A1HTTLMNA | |
| SCHEMBL21392292 | 0.70 | ALDH1A1 (0.35) | CACNA1BALDH1A1LMNAKDM4EUSP2 | |
| SCHEMBL21392335 | 0.69 | MLYCD (0.35) | CACNA1BAPLNRSMN1; SMN2ALDH1A1HTT | |
| SCHEMBL21392038 | 0.68 | MAPT (0.35) | SMN1; SMN2TRPM8LMNAKDM4EUSP2 | |
| SCHEMBL21392162 | 0.68 | APLNR (0.36) | BRD4APLNRSMN1; SMN2ALDH1A1HTT | |
| SCHEMBL21392148 | 0.68 | LMNA (0.33) | CACNA1BAPLNRALDH1A1SLC2A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019180244-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | STEP PHARMA S.A.S. (FR) | 2019-09-26 | — | — | WO | disclosed |
| WO-2019179652-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | STEP PHARMA S.A.S. (FR) | 2019-09-26 | — | — | WO | disclosed |