Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 11/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | HPD | P32754 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2141185 | 1.00 | PSEN1 (0.43) | PSEN1LMNAGAAALOX5MAPT | |
| SCHEMBL9659347 | 0.88 | PSEN1 (0.41) | PSEN1LMNAGAAALOX5MAPT | |
| SCHEMBL9659335 | 0.88 | PSEN1 (0.41) | PSEN1LMNAGAAALOX5MAPT | |
| SCHEMBL9659584 | 0.88 | PSEN1 (0.41) | PSEN1LMNAGAAALOX5MAPT | |
| SCHEMBL11601582 | 0.84 | PSEN1 (0.42) | PSEN1ALOX5MAPTTDP1PTPN1 | |
| SCHEMBL7969326 | 0.84 | PSEN1 (0.42) | PSEN1ALOX5MAPTTDP1PTPN1 | |
| SCHEMBL11601587 | 0.84 | PSEN1 (0.42) | PSEN1ALOX5MAPTTDP1PTPN1 | |
| SCHEMBL8308667 | 0.84 | PSEN1 (0.45) | PSEN1LMNAGAAMAPTMAPK1 | |
| SCHEMBL10752967 | 0.82 | ALOX5 (0.46) | PSEN1ALOX5PTPN1 | |
| SCHEMBL20503424 | 0.82 | PSEN1 (0.43) | PSEN1LMNAGAAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148424-B2 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof | RESEARCH DEVELOPMENT FOUNDATION (US) | 2012-04-03 | — | — | US | disclosed |
| US-20100303899-A1 | TOCOPHEROLS, TOCOTRIENOLS, OTHER CHROMAN AND SIDE CHAIN DERIVATIVES AND USES THEREOF | SANDERS BOB G | 2010-12-02 | — | — | US | disclosed |
| US-7718814-B2 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof | RESEARCH DEVELOPMENT FOUNDATION (US) | 2010-05-18 | — | — | US | disclosed |
| EP-1115398-B1 | TOCOPHEROLS, TOCOTRIENOLS, OTHER CHROMAN AND SIDE CHAIN DERIVATIVES AND USES THEREOF | RES DEV FOUNDATION (US) | 2010-05-05 | — | — | EP | disclosed |
| US-7608638-B2 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof | RESEARCH DEVELOPMENT FOUNDATION (US) | 2009-10-27 | — | — | US | disclosed |
| US-20080161349-A1 | TOCOPHEROLS, TOCOTRIENOLS, OTHER CHROMAN AND SIDE CHAIN DERIVATIVES AND USES THEREOF | RESEARCH DEVELOPMENT FOUNDATION (US) | 2008-07-03 | — | — | US | disclosed |
| EP-1254130-B1 | TOCOPHEROLS, TOCOTRIENOLS, OTHER CHROMAN AND SIDE CHAIN DERIVATIVES AND USES THEREOF | RES DEV FOUNDATION (US) | 2008-01-02 | — | — | EP | disclosed |
| US-7300954-B2 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof | RESEARCH DEVELOPMENT FOUNDATION (US) | 2007-11-27 | — | — | US | disclosed |
| US-20040235938-A1 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof | RESEARCH DEVELOPMENT FOUNDATION | 2004-11-25 | — | — | US | disclosed |
| US-6770672-B1 | ANTIPROLIFERATIVE, APOPTOTIC, IMMUNOMODULATING, VIRICIDAL, AND ANTICARCINOGENIC AGENTS | RESEARCH DEVELOPMENT FOUNDATION | 2004-08-03 | — | — | US | disclosed |
| US-4544758-A | Vitamin E intermediates and methods for the preparation of (2R,4'RS,8'RS)-α-tocopherol and (all-rac)-α-tocopherol via the new intermediate products | BASF AKTIENGESELLSCHAFT (DE) | 1985-10-01 | — | — | US | disclosed |
| US-4515975-A | Chroman derivatives and their preparation | BASF AKTIENGESELLSCHAFT (DE) | 1985-05-07 | — | — | US | disclosed |
| EP-0052731-B1 | CHROMAN DERIVATIVES AND METHOD FOR THEIR PREPARATION | BASF Aktiengesellschaft (DE) | 1985-04-17 | — | — | EP | disclosed |
| EP-0052731-A1 | Chroman derivatives and method for their preparation | BASF Aktiengesellschaft (DE) | 1982-06-02 | — | — | EP | disclosed |
| US-4208331-A | Synthesis of optically active vitamin E | HOFFMANN-LA ROCHE INC. (US) | 1980-06-17 | — | — | US | disclosed |
| US-4208332-A | Synthesis of optically active vitamin E | HOFFMANN-LA ROCHE INC. (US) | 1980-06-17 | — | — | US | disclosed |
| US-4189612-A | S-(+) 2,3,6-trimethyl-5-(2,2,4-trimethyl-1,3-dioxolane-4-ethyl)phenol | HOFFMANN-LA ROCHE INC. (US) | 1980-02-19 | — | — | US | disclosed |
| US-4182719-A | Synthesis of optically active vitamin E | HOFFMAN-LA ROCHE INC. (US) | 1980-01-08 | — | — | US | disclosed |
| US-4151177-A | Synthesis of optically active vitamin E | HOFFMANN-LA ROCHE INC. (US) | 1979-04-24 | — | — | US | disclosed |
| US-4113740-A | Synthesis of optically active vitamin E | HOFFMANN-LA ROCHE INC. (US) | 1978-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100303899-A1 | TOCOPHEROLS, TOCOTRIENOLS, OTHER CHROMAN AND SIDE CHAIN DERIVATIVES AND USES THEREOF | TST, TXNRD3, TXNRD1 | PSEN1 3935/4885LMNA 1979/4885GAA 3322/4885 |
| US-20040235938-A1 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof | TXN, TXN2, TTPA | PSEN1 2534/4885LMNA 434/4885GAA 3330/4885 |
| US-20080161349-A1 | TOCOPHEROLS, TOCOTRIENOLS, OTHER CHROMAN AND SIDE CHAIN DERIVATIVES AND USES THEREOF | TST, TXNRD3, TXNRD1 | PSEN1 3869/4885LMNA 1969/4885GAA 3287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.