SCHEMBL2147791

SCHEMBL2147791

Cn1nnc(-c2ccc(B3OC(C)(C)C(C)(C)O3)cn2)n1

nearest known ligand 0.44

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 2/20 0.44
LPL P06858 10/20 0.38
LIPG Q9Y5X9 10/20 0.38
PPARA Q07869 1/20 0.34
MAOA P21397 1/20 0.34
MAOB P27338 1/20 0.34
FFAR1 O14842 1/20 0.32
IRAK4 Q9NWZ3 1/20 0.32
USP30 Q70CQ3 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA9 Q16790 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29406802 1.00 DGAT1 (0.44) DGAT1LPLLIPGPPARAMAOA
SCHEMBL22238944 0.84 MAOA (0.34) DGAT1PPARAMAOAMAOB
SCHEMBL13429939 0.80 DGAT1 (0.44) DGAT1LPLLIPGFFAR1
SCHEMBL3233070 0.80 LPL (0.53) LPLLIPGPPARACA1CA2
SCHEMBL12461124 0.80 DGAT1 (0.44) DGAT1LPLLIPGPPARAFFAR1
SCHEMBL13456682 0.79 DGAT1 (0.43) DGAT1LPLLIPG
SCHEMBL13429886 0.79 DGAT1 (0.46) DGAT1LPLLIPGFFAR1IRAK4
SCHEMBL20068614 0.79 DGAT1 (0.56) DGAT1LPLLIPGFFAR1CA1
SCHEMBL3220509 0.78 DGAT1 (0.44) DGAT1LPLLIPGFFAR1IRAK4
SCHEMBL13429960 0.77 DGAT1 (0.44) DGAT1LPLLIPGFFAR1IRAK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114933596-B Preparation method of tedizolid 河北广祥制药有限公司 2023-09-05 CN claimed
CN-115792047-A Method for detecting tedizolid phosphate intermediate related substances 四川美域高生物医药科技有限公司 2023-03-14 CN claimed
CN-114933596-A Preparation method of tedizolid 河北广祥制药有限公司 2022-08-23 CN claimed
CN-106146485-B Method for preparing tedizolid and tedizolid crystal obtained by method 上海迪赛诺化学制药有限公司 2021-04-30 CN claimed
WO-2016009401-A2 PREPARATION OF TEDIZOLID PHOSPHATE DR. REDDY'S LABORATORIES LIMITED (IN) 2016-01-21 WO claimed
CN-113214288-B Benzo [1,3] oxazine-oxazolidinone compound and preparation method and application thereof 中国医学科学院药物研究所 2023-11-03 CN disclosed
CN-114933596-B Preparation method of tedizolid 河北广祥制药有限公司 2023-09-05 CN disclosed
CN-113214239-B Tedizolid refining process and preparation method of tedizole phosphate 海南通用康力制药有限公司 2023-04-07 CN disclosed
CN-115792047-A Method for detecting tedizolid phosphate intermediate related substances 四川美域高生物医药科技有限公司 2023-03-14 CN disclosed
US-20230045135-A1 TEDIZOLID INTERMEDIATE AND EFFICIENT PREPARATION METHOD THEREOF NANJING CHEMPION BIOTECHNOLOGY CO., LTD. (CN) 2023-02-09 US disclosed
CN-114933596-A Preparation method of tedizolid 河北广祥制药有限公司 2022-08-23 CN disclosed
CN-114105968-A Method for removing palladium residue of tedizolid 河北明吉化工科技有限公司 2022-03-01 CN disclosed
US-20100069441-A1 ANTIMICROBIAL INDOLINE COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS GORDEEV MIKHAIL FEDOROVICH 2010-03-18 US disclosed
US-20100069441-A1 ANTIMICROBIAL INDOLINE COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS GORDEEV MIKHAIL FEDOROVICH 2010-03-18 US disclosed
EP-2134721-A1 ANTIMICROBIAL HETEROCYCLIC COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS Micurx Pharmaceuticals, Inc. (US) 2009-12-23 EP disclosed
US-20090048305-A1 Antimicrobial ortho-Fluorophenyl Oxazolidinones For Treatment of Bacterial Infections SHANGHAI MICURX PHARMACEUTICAL CO. LTD. (CN) 2009-02-19 US disclosed
US-20090048305-A1 Antimicrobial ortho-Fluorophenyl Oxazolidinones For Treatment of Bacterial Infections SHANGHAI MICURX PHARMACEUTICAL CO. LTD. (CN) 2009-02-19 US disclosed
WO-2009020616-A1 ANTIMICROBIAL ORTHO-FLUOROPHENYL OXAZOLIDINONES FOR TREATMENT OF BACTERIAL INFECTIONS MICURX PHARMACEUTICALS, INC. (KY) 2009-02-12 WO disclosed
WO-2008108988-A1 ANTIMICROBIAL HETEROCYCLIC COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS MICURX PHARMACEUTICALS, INC. (US) 2008-09-12 WO disclosed
WO-2008108988-A1 ANTIMICROBIAL HETEROCYCLIC COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS MICURX PHARMACEUTICALS, INC. (US) 2008-09-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100069441-A1 ANTIMICROBIAL INDOLINE COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS IDO1, IDO2, INMT DGAT1 3118/4885LPL 4201/4885LIPG 3592/4885
US-20090048305-A1 Antimicrobial ortho-Fluorophenyl Oxazolidinones For Treatment of Bacterial Infections OXA1L, OGFOD1, OLA1 DGAT1 2252/4885LPL 2411/4885LIPG 2666/4885
US-20230045135-A1 TEDIZOLID INTERMEDIATE AND EFFICIENT PREPARATION METHOD THEREOF DNMT3A, DNMT1, TET2 DGAT1 4096/4885LPL 4143/4885LIPG 4858/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.