SCHEMBL214852

SCHEMBL214852

C[CH]S(=O)(=O)c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TLR9 Q9NR96 2/20 0.58
ALDH1A1 P00352 4/20 0.50
CYP1A2 P05177 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
MCOLN3 Q8TDD5 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
HTR6 P50406 1/20 0.50
PSIP1 O75475 1/20 0.48
HSD17B10 Q99714 2/20 0.46
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
TDP1 Q9NUW8 1/20 0.46
CA12 O43570 1/20 0.46
CA3 P07451 1/20 0.46
CA4 P22748 1/20 0.46
CA6 P23280 1/20 0.46
CA5A P35218 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1035736 0.80 TLR9 (0.67) TLR9ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL1035737 0.80 TLR9 (0.67) TLR9ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL10150411 0.80 TLR9 (0.67) TLR9ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL2787588 0.78 TLR9 (0.80) TLR9ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL1344341 0.78 TLR9 (0.80) TLR9ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL7541319 0.78 TLR9 (0.64) TLR9ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL1344338 0.78 TLR9 (0.80) TLR9ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL343050 0.77 TLR9 (0.70) TLR9ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL7124038 0.76 TLR9 (0.61) TLR9ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL758697 0.75 CA2 (0.50) TLR9CA1CA2CA12CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1056 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230018780-A1 METHOD FOR PRODUCING OLIGONUCLEIC ACID COMPOUND NIPPON SHINYAKU CO., LTD. (JP) 2023-01-19 US claimed
US-20230014840-A1 METHOD FOR PRODUCING OLIGONUCLEIC ACID COMPOUND NIPPON SHINYAKU CO., LTD. (JP) 2023-01-19 US claimed
CN-114981281-A Method for producing oligonucleotide compound 日本新药株式会社 2022-08-30 CN claimed
CN-114981280-A Method for producing oligonucleotide compound 日本新药株式会社 2022-08-30 CN claimed
WO-2021095874-A1 METHOD FOR PRODUCING OLIGONUCLEIC ACID COMPOUND 日本新薬株式会社 2021-05-20 WO claimed
WO-2021095875-A1 METHOD FOR PRODUCING OLIGONUCLEIC ACID COMPOUND 日本新薬株式会社 2021-05-20 WO claimed
US-20210024919-A1 FUNCTIONALIZED SOLID SUPPORT MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2021-01-28 US claimed
US-20200256862-A1 FUNCTIONALIZED SOLID SUPPORT MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2020-08-13 US claimed
US-8846898-B2 Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotide having reduced internucleotide charge Lieure Cornu LLC (US) 2014-09-30 US claimed
EP-2066662-B1 SERINE HYDROLASE INHIBITORS KYORIN SEIYAKU KK (JP) 2012-12-05 EP claimed
EP-0920414-A1 MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA & UPJOHN S.p.A. (IT) 1999-06-09 EP claimed
WO-1999014238-A1 PROCESS FOR THE PREPARATION OF CALCITONIN HYUNDAI PHARM. IND. CO., LTD. (KR) 1999-03-25 WO claimed
WO-1999002510-A1 MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA & UPJOHN S.P.A. (IT) 1999-01-21 WO claimed
US-5859256-A CHLORINATION; USEFUL AS ANTIBACTERIAL AGENTS AND IN TREATING DISEASES CAUSED BY ORGANISMS WHICH ARE RESISTANT TO BETA-LACTAM ANTIBIOTICS MICROCIDE PHARMACEUTICALS, INC. (US) 1999-01-12 US claimed
EP-0874854-A2 CEPHALOSPORIN ANTIBIOTICS Microcide Pharmaceuticals, Inc. (US) 1998-11-04 EP claimed
WO-1997049674-A1 MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA & UPJOHN S.P.A. (IT) 1997-12-31 WO claimed
WO-1997013772-A2 CEPHALOSPORIN ANTIBIOTICS MICROCIDE PHARMACEUTICALS, INC. (US) 1997-04-17 WO claimed
EP-0635500-A1 5,6-Dihydro-(4H)1,3-oxazine and -thiazine derivatives as insecticides YASHIMA CHEMICAL INDUSTRY CO., LTD. (JP) 1995-01-25 EP claimed
EP-0006693-A1 N-substituted trialkylstannylhydrocarbylcarboxylic acid hydrazides, methods of their preparation and insecticide compositions containing them UNIROYAL, INC. (US) 1980-01-09 EP claimed
US-4178382-A INSECTICIDE FOR COTTON UNIROYAL, INC. (US) 1979-12-11 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230018780-A1 METHOD FOR PRODUCING OLIGONUCLEIC ACID COMPOUND POLRMT, POLR2H, POLM TLR9 1780/4885ALDH1A1 3846/4885CYP1A2 4633/4885
US-20230014840-A1 METHOD FOR PRODUCING OLIGONUCLEIC ACID COMPOUND DNASE1, XRN2, FBL TLR9 1775/4885ALDH1A1 979/4885CYP1A2 2387/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.