SCHEMBL215902

SCHEMBL215902

O=C(CI)NN1C(=O)CCC1=O

nearest known ligand 0.37

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.37
ALDH1A1 P00352 5/20 0.35
ALOX12 P18054 1/20 0.35
MAPT P10636 1/20 0.31
RAB9A P51151 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
GAA P10253 2/20 0.30
LMNA P02545 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13182184 0.78 KDM4E (0.44) KDM4EALDH1A1ALOX12MAPTNPSR1
SCHEMBL29018280 0.75 KDM4E (0.45) KDM4EALDH1A1ALOX12MAPTRAB9A
SCHEMBL11527806 0.74 KDM4E (0.48) KDM4EALDH1A1ALOX12MAPTL3MBTL1
SCHEMBL31299898 0.74 KDM4E (0.39) KDM4EALDH1A1ALOX12MAPTL3MBTL1
SCHEMBL122496 0.74 KDM4E (0.38) KDM4EALDH1A1ALOX12MAPTRAB9A
SCHEMBL6324088 0.72 MAPT (0.67) KDM4EALDH1A1MAPTGAAMEN1
SCHEMBL26099241 0.72 KDM4E (0.37) KDM4EALDH1A1ALOX12MAPTMEN1
SCHEMBL1162244 0.72 KDM4E (0.38) KDM4EALDH1A1ALOX12MAPTRAB9A
SCHEMBL7749425 0.71 ALDH1A1 (0.38) KDM4EALDH1A1ALOX12MAPTRAB9A
SCHEMBL16327606 0.70 L3MBTL1 (0.47) KDM4EALDH1A1ALOX12MAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 322 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240218050-A1 Cysteine Engineered Antibodies and Conjugates GENENTECH, INC. (US) 2024-07-04 US disclosed
EP-3269737-B1 ANTI-CD79B ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE GENENTECH INC (US) 2024-06-19 EP disclosed
US-11873330-B2 Cysteine engineered antibodies and conjugates GENENTECH, INC. (US) 2024-01-16 US disclosed
US-11866496-B2 Humanized anti-CD79B antibodies and immunoconjugates and methods of use GENENTECH, INC. (US) 2024-01-09 US disclosed
EP-4238988-A1 ANTIBODIES AGAINST SARS-COV-2 AND USES THEREOF Consejo Superior De Investigaciones Científicas (ES) 2023-09-06 EP disclosed
US-20230227502-A1 COMPOSITIONS AND METHODS FOR MODULATING MYOSIN SUBFRAGMENT-2 COILED COIL STABILITY AND METHODS FOR USING THEM UNIV NORTH TEXAS (US) 2023-07-20 US disclosed
EP-4182345-A1 INTERLEUKIN 11 RECEPTOR ALPHA SUBUNIT (IL11RA) NEUTRALIZING ANTIBODIES AND USES THEREOF Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) (ES) 2023-05-24 EP disclosed
US-20230130874-A1 Cysteine Engineered Antibodies and Conjugates GENENTECH, INC. (US) 2023-04-27 US disclosed
CN-114246952-A Cysteine engineered antibodies and conjugates 基因泰克公司 2022-03-29 CN disclosed
US-20220023437-A1 HUMANIZED ANTI-CD79B ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE GENENTECH, INC. (US) 2022-01-27 US disclosed
WO-2004007537-A2 MODIFIED ADENOVIRAL FIBER WITH ABLATED TO CELLULAR RECEPTORS TRANSGENE S.A. (FR) 2004-01-22 WO disclosed
US-20030166549-A1 Targeting peptides TRANSGENE S.A. (FR) 2003-09-04 US disclosed
US-20030165477-A1 Poxvirus with targeted infection specificity TRANSGENE S.A. (FR) 2003-09-04 US disclosed
US-6562632-B1 Reactive dye for use as diagnostic tool in the analysis of biological systems MOLECULAR PROBES, INC. 2003-05-13 US disclosed
WO-2002092554-A1 COMPLEXES FOR TRANSFERRING SUBSTANCES OF INTEREST INTO A CELL TRANSGENE S.A. (FR) 2002-11-21 WO disclosed
EP-1254163-A2 TARGETING PEPTIDES TRANSGENE S.A. (FR) 2002-11-06 EP disclosed
EP-1146125-A1 Poxvirus with targeted infection specificity TRANSGENE S.A. (FR) 2001-10-17 EP disclosed
WO-2001057069-A2 TARGETING PEPTIDES TRANSGENE S.A. (FR) 2001-08-09 WO disclosed
US-5798276-A DETECTING COMPLEMENTARY MEMBER OF SPECIFIC BINDING PAIR USING FLUORESCENT CONJUGATE MOLECULAR PROBES, INC. (US) 1998-08-25 US disclosed
EP-0196669-A2 Improved method of conjugating metallothionein to biologically active molecules THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1986-10-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220023437-A1 HUMANIZED ANTI-CD79B ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE CD99, CD79B, CD47 KDM4E 1925/4885ALDH1A1 2739/4885ALOX12 3819/4885
US-20230130874-A1 Cysteine Engineered Antibodies and Conjugates GCLC, CTH, CBS KDM4E 4419/4885ALDH1A1 1572/4885ALOX12 4351/4885
US-20240218050-A1 Cysteine Engineered Antibodies and Conjugates CTH, LNPEP, CARS1 KDM4E 1568/4885ALDH1A1 1914/4885ALOX12 4878/4885
US-11873330-B2 Cysteine engineered antibodies and conjugates CTH, LNPEP, CARS1 KDM4E 1568/4885ALDH1A1 1914/4885ALOX12 4878/4885
US-11866496-B2 Humanized anti-CD79B antibodies and immunoconjugates and methods of use CD99, CD79B, CD47 KDM4E 1925/4885ALDH1A1 2739/4885ALOX12 3819/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.