Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21643747 | 0.79 | TSHR (0.55) | TSHRNPC1RAB9ADRD2TBXA2R | |
| SCHEMBL20715541 | 0.70 | RAB9A (0.77) | TSHRNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL4930362 | 0.69 | MAT2A (0.57) | TSHRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL11898237 | 0.69 | LMNA (0.64) | CYP1A2CYP3A4CYP2D6CYP2C19NPC1 | |
| SCHEMBL1170145 | 0.68 | SMN1; SMN2 (0.48) | TSHRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL28806937 | 0.67 | TP53 (0.57) | CYP1A2CYP3A4CYP2C19NPC1RAB9A | |
| SCHEMBL20715689 | 0.66 | MAPT (0.76) | TSHRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5928731 | 0.66 | TSHR (0.60) | TSHRNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL1170660 | 0.66 | ALDH1A1 (0.86) | CYP1A2CYP3A4CYP2D6CYP2C19NPC1 | |
| SCHEMBL28809095 | 0.66 | TP53 (0.55) | NPC1RAB9ASMN1; SMN2KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10934255-B2 | Nrf and HIF activators/HDAC inhibitors and therapeutic methods using the same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2021-03-02 | — | — | US | disclosed |
| US-20200039933-A1 | NRF AND HIF ACTIVATORS/HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2020-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934255-B2 | Nrf and HIF activators/HDAC inhibitors and therapeutic methods using the same | HIF1AN, KEAP1, NFE2L2 | TSHR 3525/4885CYP1A2 3324/4885CYP3A4 3970/4885 |
| US-20200039933-A1 | NRF AND HIF ACTIVATORS/HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | HIF1AN, KEAP1, NFE2L2 | TSHR 3525/4885CYP1A2 3324/4885CYP3A4 3970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.