Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.60 |
| ▸ | CCR3 | P51677 | 2/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29090112 | 0.84 | DRD2 (0.72) | DRD2CCR3OPRL1OPRM1OPRD1 | |
| SCHEMBL16249345 | 0.80 | DRD2 (0.67) | DRD2CCR3OPRL1OPRM1OPRD1 | |
| SCHEMBL3126817 | 0.79 | OPRM1 (0.46) | DRD2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL3640272 | 0.79 | OPRM1 (0.46) | DRD2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL3876399 | 0.79 | OPRM1 (0.50) | DRD2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL8986023 | 0.78 | DRD2 (0.64) | DRD2CCR3OPRL1OPRM1OPRD1 | |
| SCHEMBL22870543 | 0.78 | DRD2 (0.64) | DRD2CCR3OPRL1OPRM1OPRD1 | |
| SCHEMBL42581 | 0.78 | OPRL1 (0.52) | OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL11362121 | 0.77 | OPRM1 (0.44) | DRD2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL187716 | 0.75 | DRD2 (1.00) | DRD2CCR3OPRL1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853392-B2 | Benzamide mGluR5 positive allosteric modulators and methods of making and using same | VANDERBILT UNIVERSITY (US) | 2014-10-07 | — | — | US | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| EP-1348706-B1 | SUBSTITUTED THIAZOLE DERIVATIVES BEARING 3-PYRIDYL GROUPS, PROCESS FOR PREPARING THE SAME AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2009-08-19 | — | — | EP | claimed |
| US-20070299105-A1 | 2-Cyanopropanoic Acid Amide and Ester Derivatives and Methods of Their Use | WYETH (US) | 2007-12-27 | — | — | US | claimed |
| US-20040072876-A1 | Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-04-15 | — | — | US | claimed |
| EP-1348706-A1 | SUBSTITUTED THIAZOLE DERIVATIVES BEARING 3-PYRIDYL GROUPS, PROCESS FOR PREPARING THE SAME AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2003-10-01 | — | — | EP | claimed |
| US-20010034444-A1 | Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands | NEUROGEN CORPORATION | 2001-10-25 | — | — | US | claimed |
| US-5789410-A | TREATMENT OF SCHIZOPHRENIA, DEPRESSION, PARKINSON'S DISEASE | NEUROGEN CORPORATION (US) | 1998-08-04 | — | — | US | claimed |
| US-5773616-A | NEUROTROPSYCHOLOGICAL FOR SCHIZOPHRENIA AND ANTIDEPRESSANTS | NEUROGEN CORPORATION (US) | 1998-06-30 | — | — | US | claimed |
| US-4284638-A | Pharmaceutical compositions with central depressant and antipsychotic activity having a butyrophenone derivative which is substituted in the 4-position and a C-(2-benzofuranyl)-piperidine or C-(2-benzofuranyl)-tetrahydro-pyridine | CIBA-GEIGY CORPORATION (US) | 1981-08-18 | — | — | US | claimed |
| EP-0011606-A2 | Pharmaceutical compositions with central depressing and antipsychotic activity | CIBA-GEIGY AG (CH) | 1980-05-28 | — | — | EP | claimed |
| US-4022791-A | ANALGESICS, TRANQUILIZERS | PFIZER INC. (US) | 1977-05-10 | — | — | US | claimed |
| US-11178872-B2 | Cyclic amine compound and pest control agent | NIPPON SODA CO., LTD. (JP) | 2021-11-23 | — | — | US | disclosed |
| US-20190191702-A1 | CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT | NIPPON SODA CO., LTD. (JP) | 2019-06-27 | — | — | US | disclosed |
| EP-3456716-A1 | RING-SHAPED AMINE COMPOUND AND PEST CONTROL AGENT | NIPPON SODA CO., LTD. (JP) | 2019-03-20 | — | — | EP | disclosed |
| US-8853392-B2 | Benzamide mGluR5 positive allosteric modulators and methods of making and using same | VANDERBILT UNIVERSITY (US) | 2014-10-07 | — | — | US | disclosed |
| US-4061637-A | CNS, CARDIOVASCULAR, ANTIINFLAMMATORY, ADRENOLYTIC, ANTIULCER | ISTITUTO LUSO FARMACO D'ITALIA S.R.L. (IT) | 1977-12-06 | — | — | US | disclosed |
| US-4046762-A | CENTRAL NERVOUS SYSTEM INHIBITORS | INSTITUTO LUSO FARMACO D'ITALIA S.R.L. (IT) | 1977-09-06 | — | — | US | disclosed |
| US-3988475-A | ANAESTHETICS, ANTIARRHYTHMIA, HYPOTENSIVES, ADRENERGIC | ISTITUTO LUSO FARMACO D'ITALIA S.R.L. (IT) | 1976-10-26 | — | — | US | disclosed |
| US-3951978-A | ANALGESIC, ANTIARRHYTHMIC, CENTRAL NERVOUS DEPRESSANT | ISTITUTO LUSO FARMACO D'ITALIA S.R.L. (IT) | 1976-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072876-A1 | Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof | CYP17A1, CYP21A2, HSD17B1 | DRD2 4715/4885CCR3 1000/4885OPRL1 2228/4885 |
| US-20070299105-A1 | 2-Cyanopropanoic Acid Amide and Ester Derivatives and Methods of Their Use | HCAR2, PCCA, MCCC2 | DRD2 4174/4885CCR3 312/4885OPRL1 4024/4885 |
| US-20190191702-A1 | CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT | H1-4, H1-10, NPR1 | DRD2 717/4885CCR3 297/4885OPRL1 3008/4885 |
| US-20010034444-A1 | Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands | DBH, XDH, DRD2 | DRD2 3/4885CCR3 1365/4885OPRL1 30/4885 |
| US-11178872-B2 | Cyclic amine compound and pest control agent | H1-4, H1-10, NPR1 | DRD2 717/4885CCR3 297/4885OPRL1 3008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.