Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | DRD4 | P21917 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170332 | 0.90 | ALDH1A1 (0.53) | TSHRSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2171705 | 0.86 | MEN1 (0.60) | TSHRSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2170811 | 0.86 | MAPT (0.54) | ALDH1A1MEN1KMT2ADRD4MAPT | |
| SCHEMBL2170108 | 0.85 | LMNA (0.52) | SMN1; SMN2ALDH1A1MEN1KMT2ADRD4 | |
| SCHEMBL2171096 | 0.83 | SCN9A (0.51) | TSHRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL2354704 | 0.83 | ALDH1A1 (0.50) | TSHRSMN1; SMN2ALDH1A1DRD4MAPT | |
| SCHEMBL2170146 | 0.83 | SCN9A (0.48) | ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2170255 | 0.82 | ALDH1A1 (0.57) | TSHRSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2169958 | 0.82 | SCN9A (0.47) | ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2170398 | 0.81 | ALDH1A1 (0.51) | TSHRSMN1; SMN2ALDH1A1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349252-A2 | SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |