Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 1/20 | 0.48 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170768 | 0.90 | ESR1 (0.45) | ESR1LMNAMAPTCNR1HTT | |
| SCHEMBL2170359 | 0.89 | MAPT (0.48) | HSD17B2ESR1LMNAMAPTNPSR1 | |
| SCHEMBL2170067 | 0.89 | CCNT1 (0.50) | LMNAMAPTHTTHTR6ALDH1A1 | |
| SCHEMBL2171609 | 0.88 | HTR6 (0.46) | LMNAMAPTHTR6ALDH1A1SMN1; SMN2 | |
| SCHEMBL2170714 | 0.88 | LMNA (0.45) | HSD17B3HSD17B2ESR1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL2169494 | 0.88 | CCNT1 (0.49) | LMNAMAPTHTTHTR6ALDH1A1 | |
| SCHEMBL2171331 | 0.86 | FFAR4 (0.48) | LMNAMAPTHTR6FFAR4SMN1; SMN2 | |
| SCHEMBL2171351 | 0.85 | LMNA (0.52) | ESR1LMNAMAPTCNR1HTT | |
| SCHEMBL2170559 | 0.82 | SLC22A12 (0.47) | LMNAMAPTHTTHTR6ALDH1A1 | |
| SCHEMBL2170713 | 0.81 | L3MBTL1 (0.49) | ESR1LMNAHTTHTR6FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346847-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | Suven Life Sciences Limited (IN) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010032258-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2010-03-25 | — | — | WO | disclosed |