Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170359 | 0.90 | MAPT (0.48) | ESR1LMNAMAPTHTR6PGR | |
| SCHEMBL2170564 | 0.90 | HSD17B3 (0.48) | ESR1LMNAALDH1A1MAPTMAPK1 | |
| SCHEMBL2170067 | 0.90 | CCNT1 (0.50) | LMNAALDH1A1MAPTTDP1SMN1; SMN2 | |
| SCHEMBL2171609 | 0.89 | HTR6 (0.46) | LMNAALDH1A1MAPTGFERSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2169494 | 0.89 | CCNT1 (0.49) | LMNAALDH1A1MAPTTDP1SMN1; SMN2 | |
| SCHEMBL2169824 | 0.87 | ESR1 (0.45) | ESR1CYP19A1LMNAALDH1A1MAPT | |
| SCHEMBL2171331 | 0.85 | FFAR4 (0.48) | LMNAMAPTSMN1; SMN2HTR6TP53 | |
| SCHEMBL2170559 | 0.83 | SLC22A12 (0.47) | LMNAALDH1A1MAPTMCL1HTR6 | |
| SCHEMBL2170714 | 0.80 | LMNA (0.45) | ESR1LMNAALDH1A1MAPTMAPK1 | |
| SCHEMBL2170956 | 0.80 | BRD4 (0.41) | MAPTHTR6POLBCCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346847-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | Suven Life Sciences Limited (IN) | 2011-07-27 | — | — | EP | claimed |
| WO-2010032258-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2010-03-25 | — | — | WO | claimed |