Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.43 |
| ▸ | BRD1 | O95696 | 1/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR1D | P28221 | 2/20 | 0.41 |
| ▸ | HTR1B | P28222 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170768 | 0.89 | ESR1 (0.45) | HTR6PGRMAPTTHRBALDH1A1 | |
| SCHEMBL2170359 | 0.88 | MAPT (0.48) | HTR6PGRMAPTLMNAPKM | |
| SCHEMBL2170564 | 0.88 | HSD17B3 (0.48) | HTR6MAPTALDH1A1LMNAPKM | |
| SCHEMBL2170067 | 0.88 | CCNT1 (0.50) | HTR6PGRMAPTALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL2169494 | 0.87 | CCNT1 (0.49) | HTR6PGRMAPTALDH1A1LMNA | |
| SCHEMBL2236877 | 0.84 | HTR6 (0.40) | HTR6DRD2DRD3KCNH2TRIM24 | |
| SCHEMBL2171331 | 0.83 | FFAR4 (0.48) | HTR6DRD2DRD3KCNH2MAPT | |
| SCHEMBL2171076 | 0.82 | SLC2A1 (0.46) | HTR6PGRDRD2DRD3KCNH2 | |
| SCHEMBL2170559 | 0.81 | SLC22A12 (0.47) | HTR6PGRMAPTALDH1A1LMNA | |
| SCHEMBL2170956 | 0.78 | BRD4 (0.41) | HTR6MAPTHTR1AHTR1BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346847-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | Suven Life Sciences Limited (IN) | 2011-07-27 | — | — | EP | claimed |
| WO-2010032258-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2010-03-25 | — | — | WO | claimed |