Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 10/20 | 0.47 |
| ▸ | DPP4 | P27487 | 3/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GPR34 | Q9UPC5 | 2/20 | 0.39 |
| ▸ | TACR2 | P21452 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FCER2 | P06734 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2169808 | 0.94 | SCN9A (0.48) | SCN9ADPP4DPP7ALDH1A1GPR34 | |
| SCHEMBL2171096 | 0.86 | SCN9A (0.51) | SCN9AALDH1A1GPR34KMT2A | |
| SCHEMBL2171621 | 0.84 | QRFPR (0.50) | SCN9AALDH1A1GPR34 | |
| SCHEMBL2171851 | 0.84 | KMT2A (0.53) | SCN9AALDH1A1TACR2KMT2A | |
| SCHEMBL2170108 | 0.83 | LMNA (0.52) | SCN9AALDH1A1KMT2A | |
| SCHEMBL2169958 | 0.82 | SCN9A (0.47) | SCN9AALDH1A1KMT2A | |
| SCHEMBL2170398 | 0.82 | ALDH1A1 (0.51) | SCN9AALDH1A1 | |
| SCHEMBL2172994 | 0.82 | POLB (0.52) | SCN9AALDH1A1GPR34TACR2FCER2 | |
| SCHEMBL2170146 | 0.80 | SCN9A (0.48) | SCN9AALDH1A1TACR2KMT2A | |
| SCHEMBL2170811 | 0.80 | MAPT (0.54) | SCN9AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349252-A2 | SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |