Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.51 |
| ▸ | GPR34 | Q9UPC5 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | FCER2 | P06734 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | FPR1 | P21462 | 2/20 | 0.41 |
| ▸ | FPR2 | P25090 | 2/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171096 | 0.86 | SCN9A (0.51) | POLBSCN9AGPR34ALDH1A1 | |
| SCHEMBL2170811 | 0.84 | MAPT (0.54) | POLBSCN9AALDH1A1 | |
| SCHEMBL2171621 | 0.83 | QRFPR (0.50) | SCN9AGPR34ALDH1A1 | |
| SCHEMBL2169808 | 0.83 | SCN9A (0.48) | SCN9AGPR34ALDH1A1TACR2 | |
| SCHEMBL2171851 | 0.83 | KMT2A (0.53) | SCN9AALDH1A1TACR2 | |
| SCHEMBL2170332 | 0.82 | ALDH1A1 (0.53) | SCN9AALDH1A1 | |
| SCHEMBL2170108 | 0.82 | LMNA (0.52) | POLBSCN9AALDH1A1 | |
| SCHEMBL2170398 | 0.82 | ALDH1A1 (0.51) | SCN9AALDH1A1 | |
| SCHEMBL2170433 | 0.82 | SCN9A (0.47) | SCN9AGPR34ALDH1A1FCER2MMP3 | |
| SCHEMBL2169958 | 0.82 | SCN9A (0.47) | SCN9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |