SCHEMBL21722984

SCHEMBL21722984

CCc1c(C(=O)O)ccc(NC(C)=O)c1Cl

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 4/20 0.54
▸ HSD17B10 Q99714 1/20 0.54
▸ ALDH1A1 P00352 5/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43
▸ RAB9A P51151 3/20 0.40
▸ CLCN2 P51788 1/20 0.39
▸ POLB P06746 2/20 0.38
▸ CYP2C19 P33261 1/20 0.38
▸ FABP4 P15090 1/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ CA1 P00915 1/20 0.37
▸ CA2 P00918 1/20 0.37
▸ CA9 Q16790 1/20 0.37
▸ NPC1 O15118 2/20 0.37
▸ MAPT P10636 1/20 0.37
▸ TSHR P16473 1/20 0.36
▸ PPARG P37231 1/20 0.36
▸ PPARA Q07869 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8856944 0.84 FABP4 (0.48) KDM4EHSD17B10ALDH1A1MEN1KMT2A
SCHEMBL5682959 0.83 KDM4E (0.47) KDM4EHSD17B10ALDH1A1MEN1KMT2A
SCHEMBL13715488 0.82 KDM4E (0.62) KDM4EHSD17B10ALDH1A1MEN1KMT2A
SCHEMBL7596917 0.81 KDM4E (0.46) KDM4EHSD17B10ALDH1A1MEN1KMT2A
SCHEMBL5682857 0.80 KDM4E (0.45) KDM4EHSD17B10ALDH1A1MEN1KMT2A
SCHEMBL8846631 0.79 TSHR (0.45) KDM4EALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL5686136 0.78 HSD17B10 (0.43) KDM4EHSD17B10ALDH1A1MEN1KMT2A
SCHEMBL8887655 0.77 KDM4E (0.42) KDM4EHSD17B10ALDH1A1MEN1KMT2A
SCHEMBL7593462 0.77 KMT2A (0.50) KDM4EHSD17B10ALDH1A1MEN1KMT2A
SCHEMBL3256019 0.76 TSHR (0.47) KDM4EALDH1A1MEN1KMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3837008-B1 SUBSTITUTED BENZAMIDES AND THEIR USE IN THERAPY PHARMACYL AB (SE) 2025-09-24 — — EP disclosed
US-20250064761-A1 SUBSTITUTED BENZAMIDES AND THEIR USE IN THERAPY PHARMACYL AB (SE) 2025-02-27 — — US disclosed
EP-3836912-B1 COMBINATIONS OF SUBSTITUTED BENZAMIDES AND 5-ASA AGENTS PHARMACYL AB (SE) 2024-05-01 — — EP disclosed
US-11896564-B2 Medical treatment for pathologic inflammation PHARMACYL AB (SE) 2024-02-13 — — US disclosed
US-11717500-B2 Treatment of spondyloarthritis PHARMACYL AB (SE) 2023-08-08 — — US disclosed
US-20220087959-A1 A NEW MEDICAL TREATMENT FOR PATHOLOGIC INFLAMMATION PHARMACYL AB (SE) 2022-03-24 — — US disclosed
US-20210299071-A1 SUBSTITUTED BENZAMIDES AND THEIR USE IN THERAPY PHARMACYL AB (SE) 2021-09-30 — — US disclosed
US-20210236441-A1 TREATMENT OF SPONDYLOARTHRITIS PHARMACYL AB (SE) 2021-08-05 — — US disclosed
EP-3836912-A1 A NEW MEDICAL TREATMENT FOR PATHOLOGIC INFLAMMATION Pharmacyl AB (SE) 2021-06-23 — — EP disclosed
EP-3837008-A2 SUBSTITUTED BENZAMIDES AND THEIR USE IN THERAPY Pharmacyl AB (SE) 2021-06-23 — — EP disclosed
WO-2020035555-A2 SUBSTITUTED BENZAMIDES AND THEIR USE IN THERAPY PHARMACYL AB (SE) 2020-02-20 — — WO disclosed
WO-2020035554-A1 A NEW MEDICAL TREATMENT FOR PATHOLOGIC INFLAMMATION PHARMACYL AB (SE) 2020-02-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11896564-B2 Medical treatment for pathologic inflammation KIT, IL5, IL6 KDM4E 2089/4885HSD17B10 1316/4885ALDH1A1 71/4885
US-20250064761-A1 SUBSTITUTED BENZAMIDES AND THEIR USE IN THERAPY BRD4, SI, BRD7 KDM4E 1423/4885HSD17B10 2271/4885ALDH1A1 719/4885
US-11717500-B2 Treatment of spondyloarthritis SPAST, IL17A, SLC10A2 KDM4E 4389/4885HSD17B10 1150/4885ALDH1A1 1318/4885
US-20210236441-A1 TREATMENT OF SPONDYLOARTHRITIS SPAST, IL17A, SLC10A2 KDM4E 4389/4885HSD17B10 1150/4885ALDH1A1 1318/4885
US-20220087959-A1 A NEW MEDICAL TREATMENT FOR PATHOLOGIC INFLAMMATION KIT, IL5, IL1B KDM4E 2094/4885HSD17B10 1208/4885ALDH1A1 73/4885
US-20210299071-A1 SUBSTITUTED BENZAMIDES AND THEIR USE IN THERAPY BRD4, SI, BRD7 KDM4E 1423/4885HSD17B10 2271/4885ALDH1A1 719/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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