Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2964417 | 1.00 | NPC1 (0.51) | NPC1RAB9AKMT2AHTR1ACES2 | |
| SCHEMBL4440609 | 0.87 | NPC1 (0.57) | NPC1RAB9AKMT2AHTR1ACES2 | |
| SCHEMBL3229012 | 0.82 | NPC1 (0.53) | NPC1RAB9AKMT2AHTR1ACES2 | |
| SCHEMBL14525329 | 0.82 | NPC1 (0.53) | NPC1RAB9AKMT2AHTR1ACES2 | |
| SCHEMBL14386089 | 0.80 | NPC1 (0.51) | NPC1RAB9AKMT2AHTR1ACES2 | |
| SCHEMBL1232311 | 0.80 | NPC1 (0.55) | NPC1RAB9AKMT2AHTR1ACES2 | |
| SCHEMBL1264082 | 0.80 | NPC1 (0.55) | NPC1RAB9AKMT2AHTR1ACES2 | |
| SCHEMBL5684870 | 0.80 | NPC1 (0.51) | NPC1RAB9AKMT2AHTR1ACES2 | |
| SCHEMBL1200723 | 0.80 | NPC1 (0.55) | NPC1RAB9AKMT2AHTR1ACES2 | |
| SCHEMBL5834937 | 0.80 | NPC1 (0.51) | NPC1RAB9AKMT2AHTR1ACES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501967-B2 | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols | LONZA AG (CH) | 2013-08-06 | — | — | US | disclosed |
| US-20120316350-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 1-SUBSTITUTED-3-AMINOALCOHOLS | LONZA AG (CH) | 2012-12-13 | — | — | US | disclosed |
| US-8258338-B2 | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols | LONZA AG (CH) | 2012-09-04 | — | — | US | disclosed |
| EP-1720852-B1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 1-SUBSTITUTED-3-AMINOALCOHOLS | LONZA AG (CH) | 2012-07-11 | — | — | EP | disclosed |
| US-8193380-B2 | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols | LONZA AG (CH) | 2012-06-05 | — | — | US | disclosed |
| CN-102392059-A | Synthetic method of (S)-(-)-N,N-dimethyl-3-hydroxy-3-(2-thiophene)propylamine | LIANYUNGANG HONGYE CHEMICAL CO LTD | 2012-03-28 | — | — | CN | disclosed |
| US-20110207946-A1 | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols | LONZA AG (CH) | 2011-08-25 | — | — | US | disclosed |
| US-7973182-B2 | enantiomerically pure 1-substituted-3-amino-alcohols, particularly of (S)-(-)- and (R)-(+)-3-N-methylamino-1-(2-thienyl)-1-propanol, by asymmetrically hydrogenating salts of a carboxylic acids with an aminoketone of the formula: | LONZA LTD. (CH) | 2011-07-05 | — | — | US | disclosed |
| US-20090156833-A1 | Process for the Preparation of Enantiomerically Pure 1-Substituted-3-Aminoalcohols | LONZA AG (CH) | 2009-06-18 | — | — | US | disclosed |
| US-20080154047-A1 | Process For the Preparation of Enantiomerically Pure1-Substitued-3-Aminoalcohols | LONZA AG (CH) | 2008-06-26 | — | — | US | disclosed |
| EP-1566383-A1 | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols | Lonza AG (CH) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004031168-A2 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF OPTICALLY ACTIVE 3-AMINO-1-(2-THIENYL)-1-PROPANOL DERIVATIVES | LONZA AG (CH) | 2004-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207946-A1 | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols | ALDH7A1, BCKDK, AASDHPPT | NPC1 4004/4885RAB9A 3731/4885KMT2A 875/4885 |
| US-20120316350-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 1-SUBSTITUTED-3-AMINOALCOHOLS | CYP2S1, AKR1C3, AKR1B10 | NPC1 3835/4885RAB9A 2680/4885KMT2A 525/4885 |
| US-20090156833-A1 | Process for the Preparation of Enantiomerically Pure 1-Substituted-3-Aminoalcohols | CYP2S1, AKR1C3, ADSL | NPC1 3958/4885RAB9A 2362/4885KMT2A 1200/4885 |
| US-20080154047-A1 | Process For the Preparation of Enantiomerically Pure1-Substitued-3-Aminoalcohols | ADH1A, ADH1C, ALDH7A1 | NPC1 3230/4885RAB9A 3538/4885KMT2A 1084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.