Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1200723 | 1.00 | NPC1 (0.55) | NPC1RAB9AKMT2AHTR1ASLC5A2 | |
| SCHEMBL1232311 | 1.00 | NPC1 (0.55) | NPC1RAB9AKMT2AHTR1ASLC5A2 | |
| SCHEMBL30949063 | 0.90 | NPC1 (0.54) | NPC1RAB9AKMT2AHTR1ASLC5A2 | |
| SCHEMBL6577417 | 0.90 | NPC1 (0.54) | NPC1RAB9AKMT2AHTR1ASLC5A2 | |
| SCHEMBL4440609 | 0.87 | NPC1 (0.57) | NPC1RAB9AKMT2AHTR1ASLC5A2 | |
| SCHEMBL6614216 | 0.83 | — | — | |
| Butyric Acid SCHEMBL27783903 | 0.83 | KMT2A (0.43) | NPC1RAB9AKMT2AHTR1ASLC5A2 | |
| SCHEMBL3229012 | 0.82 | NPC1 (0.53) | NPC1RAB9AKMT2AHTR1ASLC5A2 | |
| SCHEMBL14525329 | 0.82 | NPC1 (0.53) | NPC1RAB9AKMT2AHTR1ASLC5A2 | |
| SCHEMBL14386089 | 0.80 | NPC1 (0.51) | NPC1RAB9AKMT2AHTR1ASLC5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12570643-B2 | 3-aryloxy-3-five-membered heteroaryl propylamine compound, and crystal form and use thereof | SHANGHAI LEADO PHARMATECH CO. LTD. (CN) | 2026-03-10 | — | — | US | disclosed |
| US-12492195-B2 | Preparation method for and crystal form of 3-aryloxy-3-five-membered heteroaryl-propylamine compound | ZHANGZHOU PIEN TZE HUANG PHARMACEUTICAL CO., LTD. (CN) | 2025-12-09 | — | — | US | disclosed |
| EP-3838900-B1 | 3-ARYLOXY-3-ARYL-PROPYLAMINE COMPOUND AND USES THEREOF | ZHANGZHOU PIEN TZE HUANG PHARM (CN) | 2025-02-12 | — | — | EP | disclosed |
| US-20250042884-A1 | 3-ARYLOXYL-3-FIVE-MEMBERED HETEROARYL PROPYLAMINE COMPOUND AND USE THEREOF | SHANGHAI LEADO PHARMATECH CO. LTD. (CN) | 2025-02-06 | — | — | US | disclosed |
| US-12139476-B2 | 3-aryloxyl-3-five-membered heteroaryl propylamine compound and use thereof | SHANGHAI LEADO PHARMATECH CO. LTD. (CN) | 2024-11-12 | — | — | US | disclosed |
| CN-107840845-B | Novel use of amine compound | 上海璃道医药科技有限公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-115135644-B | Preparation method and crystal form of 3-aryloxy-3-five-membered heteroaryl-propylamine compound | 漳州片仔癀药业股份有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-114206859-B | 3-Aryloxy-3-five-membered heteroaryl-propylamine compound, and crystal forms and application thereof | 上海璃道医药科技有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-112654616-B | 3-aryloxy-3-aryl-propylamines and application thereof | 漳州片仔癀药业股份有限公司 | 2024-03-12 | — | — | CN | disclosed |
| US-20230339920-A1 | PREPARATION METHOD FOR AND CRYSTAL FORM OF 3-ARYLOXY-3-FIVE-MEMBERED HETEROARYLPROPYLAMINE COMPOUND | ZHANGZHOU PIEN TZE HUANG PHARMACEUTICAL CO., LTD. (CN) | 2023-10-26 | — | — | US | disclosed |
| EP-1670779-A2 | METHODS FOR THE PRODUCTION OF 3-METHYLAMINO-1-(THIENE-2-YL)-PROPANE-1-OL | BASF Aktiengesellschaft (DE) | 2006-06-21 | — | — | EP | disclosed |
| US-7037932-B2 | Heteroaryloxy 3-substituted propanamines as serotonin and norepinephrine reuptake inhibitors | ELI LILLY AND COMPANY (US) | 2006-05-02 | — | — | US | disclosed |
| US-20060058360-A1 | Propanamine derivatives as serotonin and norepinephrine reuptake inhibitors | ELI LILLY AND COMPANY | 2006-03-16 | — | — | US | disclosed |
| WO-2005108590-A2 | METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOLS FROM ALKANONES USING A DEHYDROGENASE OF AZOARCUS | BASF AKTIENGESELLSCHAFT (DE) | 2005-11-17 | — | — | WO | disclosed |
| EP-1397129-B1 | HETEROARYLOXY 3-SUBSTITUTED PROPANAMINES S SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITORS | LILLY CO ELI (US) | 2005-11-16 | — | — | EP | disclosed |
| US-6887871-B2 | Use of phenylheteroakylamine derivatives | ASTRAZENECA AB (SE) | 2005-05-03 | — | — | US | disclosed |
| WO-2005033094-A2 | METHODS FOR THE PRODUCTION OF 3-METHYLAMINO-1-(THIENE-2-YL)-PROPANE-1-OL | BASF AKTIENGESELLSCHAFT (DE) | 2005-04-14 | — | — | WO | disclosed |
| EP-1263711-B1 | NOVEL USE OF PHENYLHETEROALKYLAMINE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-12-15 | — | — | EP | disclosed |
| US-20040176435-A1 | Heteroaryloxy 3-substituted propanamines s serotonin and norepinephrine reuptake inhibitors | ELI LILLY AND COMPANY | 2004-09-09 | — | — | US | disclosed |
| US-20030158185-A1 | Novel use of phenylheteroakylamine derivatives | ASTRAZENECA AB (SE) | 2003-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12492195-B2 | Preparation method for and crystal form of 3-aryloxy-3-five-membered heteroaryl-propylamine compound | TRPC7, TRPV1, TRPC5 | NPC1 1103/4885RAB9A 2916/4885KMT2A 3774/4885 |
| US-20040176435-A1 | Heteroaryloxy 3-substituted propanamines s serotonin and norepinephrine reuptake inhibitors | ADRA2C, ADRB1, TPH1 | NPC1 195/4885RAB9A 2401/4885KMT2A 2480/4885 |
| US-12139476-B2 | 3-aryloxyl-3-five-membered heteroaryl propylamine compound and use thereof | TRPV1, TRPA1, TRPM5 | NPC1 463/4885RAB9A 2647/4885KMT2A 2999/4885 |
| US-20230339920-A1 | PREPARATION METHOD FOR AND CRYSTAL FORM OF 3-ARYLOXY-3-FIVE-MEMBERED HETEROARYLPROPYLAMINE COMPOUND | TRPV1, TRPC7, TRPC4 | NPC1 773/4885RAB9A 1511/4885KMT2A 3655/4885 |
| US-12570643-B2 | 3-aryloxy-3-five-membered heteroaryl propylamine compound, and crystal form and use thereof | TRPA1, TRPM7, TRPV1 | NPC1 334/4885RAB9A 2731/4885KMT2A 3639/4885 |
| US-20250042884-A1 | 3-ARYLOXYL-3-FIVE-MEMBERED HETEROARYL PROPYLAMINE COMPOUND AND USE THEREOF | TRPV1, TRPA1, TRPM5 | NPC1 463/4885RAB9A 2647/4885KMT2A 2999/4885 |
| US-20030158185-A1 | Novel use of phenylheteroakylamine derivatives | NOS1, XDH, NOS2 | NPC1 2045/4885RAB9A 2510/4885KMT2A 3267/4885 |
| US-20060058360-A1 | Propanamine derivatives as serotonin and norepinephrine reuptake inhibitors | ADRB3, SLC6A2, SLC6A3 | NPC1 323/4885RAB9A 3627/4885KMT2A 3364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.