Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20551971 | 0.89 | ADRB2 (0.53) | ADRA2AADRB2CX3CR1OPRK1OPRM1 | |
| SCHEMBL20553443 | 0.89 | OPRK1 (0.50) | ADRA2AADRB2CX3CR1OPRK1MAPT | |
| SCHEMBL20552725 | 0.86 | ADRA2A (0.42) | ADRA2AADRB2CX3CR1OPRK1OPRM1 | |
| SCHEMBL20553700 | 0.82 | ADRB2 (0.55) | ADRA2AADRB2CX3CR1OPRK1OPRM1 | |
| SCHEMBL24410084 | 0.78 | OPRK1 (0.42) | ADRA2AADRB2CX3CR1OPRK1MAPT | |
| SCHEMBL21751214 | 0.77 | ADRB2 (0.58) | ADRA2AADRB2CX3CR1OPRK1OPRM1 | |
| SCHEMBL29424028 | 0.77 | ADRB2 (0.58) | ADRA2AADRB2CX3CR1OPRK1OPRM1 | |
| SCHEMBL21751233 | 0.75 | ADRB2 (0.56) | ADRA2AADRB2CX3CR1OPRK1OPRM1 | |
| SCHEMBL21751230 | 0.72 | ADRA1A (0.40) | HTR7HTR1AHTR2CDRD2DRD1 | |
| SCHEMBL31258553 | 0.72 | ADRA1A (0.40) | HTR7HTR1AHTR2CDRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200062768-A1 | CX3CR1 Small Molecule Antagonists, and Methods Using Same | DREXEL UNIVERSITY | 2020-02-27 | — | — | US | claimed |
| US-12630555-B2 | Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists | DREXEL UNIVERSITY (US) | 2026-05-19 | — | — | US | disclosed |
| US-20240409544-A1 | SUBSTITUTED PYRROLO[1,2-a]QUINOXALIN-4(5H)-ONES AS CX3CR1 ANTAGONISTS | DREXEL UNIVERSITY | 2024-12-12 | — | — | US | disclosed |
| US-12152036-B2 | Substituted pyrrolo[1,2-α]quinoxalin-4(5H)-ones as CX3CR1 antagonists | DREXEL UNIVERSITY (US) | 2024-11-26 | — | — | US | disclosed |
| US-20220144845-A1 | SUBSTITUTED PYRROLO[1,2-a]QUINOXALIN-4(5H)-ONES AS CX3CR1 ANTAGONISTS | UNIV DREXEL (US) | 2022-05-12 | — | — | US | disclosed |
| US-20220144845-A1 | SUBSTITUTED PYRROLO[1,2-a]QUINOXALIN-4(5H)-ONES AS CX3CR1 ANTAGONISTS | UNIV DREXEL (US) | 2022-05-12 | — | — | US | disclosed |
| US-11267817-B2 | Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists | DREXEL UNIVERSITY (US) | 2022-03-08 | — | — | US | disclosed |
| US-20200062768-A1 | CX3CR1 Small Molecule Antagonists, and Methods Using Same | DREXEL UNIVERSITY | 2020-02-27 | — | — | US | disclosed |
| US-20200062768-A1 | CX3CR1 Small Molecule Antagonists, and Methods Using Same | DREXEL UNIVERSITY | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240409544-A1 | SUBSTITUTED PYRROLO[1,2-a]QUINOXALIN-4(5H)-ONES AS CX3CR1 ANTAGONISTS | CX3CR1, CCR5, CCL2 | ADRA2A 527/4885ADRB2 517/4885CX3CR1 1/4885 |
| US-20220144845-A1 | SUBSTITUTED PYRROLO[1,2-a]QUINOXALIN-4(5H)-ONES AS CX3CR1 ANTAGONISTS | CX3CR1, CCR5, CCL2 | ADRA2A 527/4885ADRB2 517/4885CX3CR1 1/4885 |
| US-20200062768-A1 | CX3CR1 Small Molecule Antagonists, and Methods Using Same | CX3CR1, CCR5, CXCR3 | ADRA2A 689/4885ADRB2 621/4885CX3CR1 1/4885 |
| US-11267817-B2 | Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists | CX3CR1, CCR5, CCL2 | ADRA2A 591/4885ADRB2 597/4885CX3CR1 1/4885 |
| US-12630555-B2 | Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists | CX3CR1, CCL2, CCR2 | ADRA2A 629/4885ADRB2 250/4885CX3CR1 1/4885 |
| US-12152036-B2 | Substituted pyrrolo[1,2-α]quinoxalin-4(5H)-ones as CX3CR1 antagonists | CX3CR1, CCR5, CCL2 | ADRA2A 493/4885ADRB2 437/4885CX3CR1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.