Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | GPR3 | P46089 | 1/20 | 0.38 |
| ▸ | RGS12 | O14924 | 2/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1049324 | 0.98 | ERAP1 (0.50) | ERAP1KDM4EMAPTALDH1A1L3MBTL1 | |
| Iodide SCHEMBL9134481 | 0.96 | PTPN1 (0.50) | ERAP1KDM4EMAPTALDH1A1L3MBTL1 | |
| SCHEMBL7250788 | 0.90 | ERAP1 (0.49) | ERAP1KDM4EMAPTALDH1A1L3MBTL1 | |
| SCHEMBL3290449 | 0.82 | LMNA (0.64) | ERAP1KDM4EMAPTALDH1A1L3MBTL1 | |
| Water SCHEMBL25364929 | 0.76 | APOBEC3A (0.35) | KDM4EMAPTALDH1A1LMNARAB9A | |
| Water SCHEMBL31338886 | 0.76 | MAPT (0.38) | KDM4EMAPTRAB9APOLBALOX15 | |
| SCHEMBL474643 | 0.75 | KDM4E (0.41) | ERAP1KDM4EMAPTALDH1A1L3MBTL1 | |
| SCHEMBL25911892 | 0.75 | GPR3 (0.38) | ERAP1KDM4EMAPTALDH1A1L3MBTL1 | |
| SCHEMBL23641666 | 0.75 | ERAP1 (0.49) | ERAP1KDM4EMAPTALDH1A1L3MBTL1 | |
| Water SCHEMBL31058792 | 0.75 | LMNA (0.50) | ERAP1KDM4EMAPTALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260048993-A1 | METHOD OF MAKING MOLECULAR SIEVES OF DON FRAMEWORK TYPE | EXXONMOBIL TECHNOLOGY & ENGINEERING COMPANY (US) | 2026-02-19 | — | — | US | disclosed |
| US-20260027546-A1 | CARBON DIOXIDE SORBENTS | EXXONMOBIL TECHNOLOGY & ENGINEERING COMPANY (US) | 2026-01-29 | — | — | US | disclosed |
| US-20250033029-A1 | COATED POROUS MONOLITH STRUCTURES | ExxonMobil Technology and Engineering Company | 2025-01-30 | — | — | US | disclosed |
| WO-2025024696-A1 | POLYAMINE SORBENTS ON HIGH PORE VOLUME SUPPORTS | ExxonMobil Technology and Engineering Company (US) | 2025-01-30 | — | — | WO | disclosed |
| US-20250033027-A1 | POLYAMINE SORBENTS ON HIGH PORE VOLUME SUPPORTS | ExxonMobil Technology and Engineering Company | 2025-01-30 | — | — | US | disclosed |
| WO-2025024699-A1 | COATED POROUS MONOLITH STRUCTURES | ExxonMobil Technology and Engineering Company (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2025024692-A2 | CARBON DIOXIDE SORBENTS | ExxonMobil Technology and Engineering Company (US) | 2025-01-30 | — | — | WO | disclosed |
| US-11827593-B2 | Production of alkylaromatic compounds | EXXONMOBIL CHEMICALS PATENTS INC. (US) | 2023-11-28 | — | — | US | disclosed |
| US-20220356132-A1 | Production of Alkylaromatic Compounds | EXXONMOBIL CHEMICAL PATENTS INC (US) | 2022-11-10 | — | — | US | disclosed |
| EP-3860950-A1 | ZEOLITE SYNTHESES AND DIRECTING AGENTS | ExxonMobil Research and Engineering Company (US) | 2021-08-11 | — | — | EP | disclosed |
| CN-112739648-A | Zeolite synthesis and directing agents | 埃克森美孚研究工程公司 | 2021-04-30 | — | — | CN | disclosed |
| WO-2021076260-A1 | PRODUCTION OF ALKYLAROMATIC COMPOUNDS | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2021-04-22 | — | — | WO | disclosed |
| US-10807875-B2 | Zeolite syntheses and directing agents | EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) | 2020-10-20 | — | — | US | disclosed |
| US-20200109058-A1 | ZEOLITE SYNTHESES AND DIRECTING AGENTS | EXXONMOBIL RES & ENG CO (US) | 2020-04-09 | — | — | US | disclosed |
| WO-2020072157-A1 | ZEOLITE SYNTHESES AND DIRECTING AGENTS | EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) | 2020-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260048993-A1 | METHOD OF MAKING MOLECULAR SIEVES OF DON FRAMEWORK TYPE | APP, HCN4, BACE1 | ERAP1 4579/4885KDM4E 759/4885MAPT 544/4885 |
| US-20220356132-A1 | Production of Alkylaromatic Compounds | MYCBP, TERT, TBCB | ERAP1 4516/4885KDM4E 2616/4885MAPT 2158/4885 |
| US-11827593-B2 | Production of alkylaromatic compounds | MYCBP, TERT, TBCB | ERAP1 4516/4885KDM4E 2616/4885MAPT 2158/4885 |
| US-20260027546-A1 | CARBON DIOXIDE SORBENTS | H1-2, H1-4, DCX | ERAP1 3805/4885KDM4E 89/4885MAPT 1062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.