SCHEMBL218424

SCHEMBL218424

Cc1cccc([C]2C=Cc3ccccc32)c1C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.38
ALDH1A1 P00352 3/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
ACHE P22303 2/20 0.38
HSD17B10 Q99714 2/20 0.38
MAPT P10636 2/20 0.38
ALOX15 P16050 2/20 0.38
KDM4E B2RXH2 1/20 0.38
BCHE P06276 1/20 0.38
POLB P06746 1/20 0.38
PTPRC P08575 1/20 0.38
THRB P10828 1/20 0.38
PKM P14618 1/20 0.38
IDO1 P14902 1/20 0.38
HPGD P15428 1/20 0.38
PTPN1 P18031 1/20 0.38
CES1 P23141 1/20 0.38
RECQL P46063 1/20 0.38
PTPN22 Q9Y2R2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2964621 0.86 LMNA (0.36) LMNAALDH1A1MEN1KMT2AACHE
SCHEMBL216367 0.85 ALDH1A1 (0.41) LMNAALDH1A1MEN1KMT2AACHE
SCHEMBL6650645 0.81 MYC (0.41) LMNAALDH1A1MEN1KMT2AACHE
SCHEMBL5921807 0.77 LMNA (0.50) LMNAALDH1A1MEN1KMT2AACHE
SCHEMBL30834716 0.74 TRPA1 (0.52) ALDH1A1ACHEPOLBTRPA1ATM
SCHEMBL218508 0.74 TRPA1 (0.52) ALDH1A1ACHEPOLBTRPA1ATM
SCHEMBL284410 0.72 TSHR (0.47) ALDH1A1ACHEIDO1TRPA1ATM
SCHEMBL218425 0.72 TRPA1 (0.34) LMNAALDH1A1ACHEKDM4EPOLB
SCHEMBL2975633 0.72 TRPA1 (0.34) ALDH1A1ACHEMAPTTRPA1ATM
Ammonia Solution, Strong SCHEMBL15862222 0.71 TRPA1 (0.50) ALDH1A1ACHEPOLBTRPA1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7276567-B2 Heterocyclic substituted metallocene compounds for olefin polymerization EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-10-02 US claimed
US-10421921-B2 Lubricants from mixed alpha-olefin feeds EXXONMOBIL CHEMICAL PATENTS INC. (US) 2019-09-24 US disclosed
EP-1920031-B1 LUBRICANTS FROM MIXED ALPHA-OLEFIN FEEDS EXXONMOBIL CHEMICAL PATENTS INC (US) 2018-01-10 EP disclosed
US-20170137737-A1 Lubricants from Mixed Alpha-Olefin Feeds EXXONMOBIL CHEMICAL PATENTS INC. 2017-05-18 US disclosed
US-9593288-B2 Lubricants from mixed alpha-olefin feeds EXXONMOBIL CHEMICAL PATENTS INC. (US) 2017-03-14 US disclosed
US-9409834-B2 Low viscosity poly-alpha-olefins EXXONMOBIL CHEMICAL PATENTS INC. (US) 2016-08-09 US disclosed
US-20150252279-A1 Lubricants From Mixed Alpha-Olefin Feeds EXXONMOBIL CHEMICAL PATENTS INC. 2015-09-10 US disclosed
US-8957159-B2 Multiple catalyst system for olefin polymerization and polymers produced therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2015-02-17 US disclosed
US-8921291-B2 Lubricants from mixed alpha-olefin feeds EXXONMOBIL CHEMICAL PATENTS INC. (US) 2014-12-30 US disclosed
US-20140378720-A1 Processes to Produce Polyalpha-Olefin Compositions EXXONMOBIL CHEMICAL PATENTS INC. 2014-12-25 US disclosed
US-7294681-B2 Mutliple catalyst system for olefin polymerization and polymers produced therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-11-13 US disclosed
US-7276567-B2 Heterocyclic substituted metallocene compounds for olefin polymerization EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-10-02 US disclosed
US-20070135597-A1 Heteroatom bridged metallocene compounds for olefin polymerization EXXONMOBIL CHEMICAL PATENTS INC. 2007-06-14 US disclosed
US-7223822-B2 Multiple catalyst and reactor system for olefin polymerization and polymers produced therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-05-29 US disclosed
US-7214747-B2 Phosphorus substituted metallocene compounds for olefin polymerization EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-05-08 US disclosed
US-7214746-B2 Phosphorus bridged metallocene compounds for olefin polymerization EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-05-08 US disclosed
US-20070043248-A1 Process to produce low viscosity poly-alpha-olefins EXXONMOBIL CHEMICAL PATENTS INC. 2007-02-22 US disclosed
US-20050261449-A1 Heterocyclic substituted metallocene compounds for olefin polymerization EXXONMOBIL CHEMICAL PATENT INC. 2005-11-24 US disclosed
US-20050239981-A1 Phosphorus bridged metallocene compounds for olefin polymerization EXXONMOBIL CHEMICAL PATENTS INC. 2005-10-27 US disclosed
US-20050239980-A1 Phosphorus substituted metallocene compounds for olefin polymerization EXXONMOBIL CHEMICAL PATENTS INC. 2005-10-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070043248-A1 Process to produce low viscosity poly-alpha-olefins AP1M1, AP3D1, AP3M1 LMNA 3684/4885ALDH1A1 3663/4885MEN1 2338/4885
US-20050239981-A1 Phosphorus bridged metallocene compounds for olefin polymerization PYM1, ZNF207, POLL LMNA 1336/4885ALDH1A1 4206/4885MEN1 521/4885
US-20070135597-A1 Heteroatom bridged metallocene compounds for olefin polymerization AP2M1, AP1M1, PYM1 LMNA 2058/4885ALDH1A1 4332/4885MEN1 750/4885
US-20050239980-A1 Phosphorus substituted metallocene compounds for olefin polymerization CCRL2, ARL1, OSBP2 LMNA 755/4885ALDH1A1 4248/4885MEN1 1786/4885
US-20140378720-A1 Processes to Produce Polyalpha-Olefin Compositions AP1M1, AP1S1, CCT4 LMNA 4060/4885ALDH1A1 3012/4885MEN1 2743/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.