SCHEMBL218425

SCHEMBL218425

Cc1cccc(C2=Cc3ccccc3[CH]2)c1C

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.34
ATM Q13315 1/20 0.34
P2RX7 Q99572 1/20 0.33
TSHR P16473 1/20 0.33
ACHE P22303 1/20 0.33
NUDT1 P36639 3/20 0.31
HTR7 P34969 1/20 0.31
MYC P01106 1/20 0.31
NPC1 O15118 1/20 0.31
CASP3 P42574 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
SENP8 Q96LD8 1/20 0.31
SENP7 Q9BQF6 1/20 0.31
SENP6 Q9GZR1 1/20 0.31
CYP2A6 P11509 2/20 0.30
ALDH1A1 P00352 1/20 0.30
POLB P06746 1/20 0.30
RECQL P46063 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL218457 0.86 NPC1 (0.38) TSHRACHEHTR7NPC1CASP3
SCHEMBL2964624 0.85 CYP1A2 (0.32) TSHRCYP2A6POLBRECQLNPSR1
SCHEMBL6650647 0.78 ACHE (0.38) TSHRACHEMYCCYP2A6ALDH1A1
SCHEMBL218424 0.72 LMNA (0.38) TRPA1ATMP2RX7TSHRACHE
SCHEMBL7943843 0.71 LMNA (0.30) TSHRACHELMNA
SCHEMBL218508 0.71 TRPA1 (0.52) TRPA1ATMP2RX7TSHRACHE
SCHEMBL30834716 0.71 TRPA1 (0.52) TRPA1ATMP2RX7TSHRACHE
SCHEMBL26149 0.71 PTPN1 (0.41) ATMTSHRSMN1; SMN2CYP2A6ALDH1A1
SCHEMBL217868 0.69 EED (0.36) ACHENPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL7931699 0.69 CYP2A6 (0.43) TSHRNPC1RAB9ASMN1; SMN2CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7276567-B2 Heterocyclic substituted metallocene compounds for olefin polymerization EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-10-02 US claimed
US-10421921-B2 Lubricants from mixed alpha-olefin feeds EXXONMOBIL CHEMICAL PATENTS INC. (US) 2019-09-24 US disclosed
EP-1920031-B1 LUBRICANTS FROM MIXED ALPHA-OLEFIN FEEDS EXXONMOBIL CHEMICAL PATENTS INC (US) 2018-01-10 EP disclosed
US-20170137737-A1 Lubricants from Mixed Alpha-Olefin Feeds EXXONMOBIL CHEMICAL PATENTS INC. 2017-05-18 US disclosed
US-9593288-B2 Lubricants from mixed alpha-olefin feeds EXXONMOBIL CHEMICAL PATENTS INC. (US) 2017-03-14 US disclosed
US-9409834-B2 Low viscosity poly-alpha-olefins EXXONMOBIL CHEMICAL PATENTS INC. (US) 2016-08-09 US disclosed
US-20150252279-A1 Lubricants From Mixed Alpha-Olefin Feeds EXXONMOBIL CHEMICAL PATENTS INC. 2015-09-10 US disclosed
US-8957159-B2 Multiple catalyst system for olefin polymerization and polymers produced therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2015-02-17 US disclosed
US-8921291-B2 Lubricants from mixed alpha-olefin feeds EXXONMOBIL CHEMICAL PATENTS INC. (US) 2014-12-30 US disclosed
US-20140378720-A1 Processes to Produce Polyalpha-Olefin Compositions EXXONMOBIL CHEMICAL PATENTS INC. 2014-12-25 US disclosed
US-7294681-B2 Mutliple catalyst system for olefin polymerization and polymers produced therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-11-13 US disclosed
US-7276567-B2 Heterocyclic substituted metallocene compounds for olefin polymerization EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-10-02 US disclosed
US-20070135597-A1 Heteroatom bridged metallocene compounds for olefin polymerization EXXONMOBIL CHEMICAL PATENTS INC. 2007-06-14 US disclosed
US-7223822-B2 Multiple catalyst and reactor system for olefin polymerization and polymers produced therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-05-29 US disclosed
US-7214747-B2 Phosphorus substituted metallocene compounds for olefin polymerization EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-05-08 US disclosed
US-7214746-B2 Phosphorus bridged metallocene compounds for olefin polymerization EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-05-08 US disclosed
US-20070043248-A1 Process to produce low viscosity poly-alpha-olefins EXXONMOBIL CHEMICAL PATENTS INC. 2007-02-22 US disclosed
US-20050261449-A1 Heterocyclic substituted metallocene compounds for olefin polymerization EXXONMOBIL CHEMICAL PATENT INC. 2005-11-24 US disclosed
US-20050239981-A1 Phosphorus bridged metallocene compounds for olefin polymerization EXXONMOBIL CHEMICAL PATENTS INC. 2005-10-27 US disclosed
US-20050239980-A1 Phosphorus substituted metallocene compounds for olefin polymerization EXXONMOBIL CHEMICAL PATENTS INC. 2005-10-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070043248-A1 Process to produce low viscosity poly-alpha-olefins AP1M1, AP3D1, AP3M1 TRPA1 1239/4885ATM 1247/4885P2RX7 4042/4885
US-20050239981-A1 Phosphorus bridged metallocene compounds for olefin polymerization PYM1, ZNF207, POLL TRPA1 1705/4885ATM 1504/4885P2RX7 1816/4885
US-20070135597-A1 Heteroatom bridged metallocene compounds for olefin polymerization AP2M1, AP1M1, PYM1 TRPA1 438/4885ATM 2370/4885P2RX7 3957/4885
US-20050239980-A1 Phosphorus substituted metallocene compounds for olefin polymerization CCRL2, ARL1, OSBP2 TRPA1 644/4885ATM 3155/4885P2RX7 1764/4885
US-20140378720-A1 Processes to Produce Polyalpha-Olefin Compositions AP1M1, AP1S1, CCT4 TRPA1 3891/4885ATM 1929/4885P2RX7 4362/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.