Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21856343 | 0.87 | TAS2R14 (0.37) | MAPK1NPSR1KMT2AMEN1UBE2M | |
| SCHEMBL21856349 | 0.84 | DDB1 (0.47) | ALDH1A1KDM4ELMNAMAPTMAPK1 | |
| SCHEMBL21856323 | 0.81 | IDH2 (0.45) | KMT2AMEN1UBE2MDCUN1D1 | |
| SCHEMBL21856357 | 0.80 | RHOC (0.40) | KMT2AMEN1UBE2MDCUN1D1 | |
| SCHEMBL21856326 | 0.80 | RHOC (0.42) | UBE2MDCUN1D1 | |
| SCHEMBL21958748 | 0.76 | TEAD1 (0.60) | ALDH1A1KDM4ETDP1LMNAMAPT | |
| SCHEMBL21958155 | 0.76 | TEAD1 (0.60) | ALDH1A1KDM4ETDP1LMNAMAPT | |
| SCHEMBL21856354 | 0.75 | EGFR (0.39) | — | |
| SCHEMBL21856350 | 0.73 | SCD (0.38) | ALDH1A1TDP1LMNAMAPTKMT2A | |
| SCHEMBL26108320 | 0.73 | TRPV1 (0.38) | MAPTPOLBTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081572-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |