Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC6 | Q9Y210 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186581 | 0.85 | KMT2A (0.52) | KMT2AALDH1A1GAALMNAMAPK1 | |
| SCHEMBL2187333 | 0.81 | MAPT (0.51) | KMT2AALDH1A1LMNATP53SMN1; SMN2 | |
| SCHEMBL2187314 | 0.81 | ALDH1A1 (0.36) | TRPC6ALDH1A1GAALMNAMAPK1 | |
| SCHEMBL2188486 | 0.78 | MAPK1 (0.40) | KMT2ANPC1ABCB1ABCC1ALDH1A1 | |
| SCHEMBL2188442 | 0.78 | NPC1 (0.47) | TRPC6KMT2ANPC1ALDH1A1GAA | |
| SCHEMBL2186813 | 0.77 | SCD5 (0.43) | TRPC6ALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL2187029 | 0.77 | L3MBTL1 (0.46) | TRPC6KMT2AALDH1A1GAALMNA | |
| SCHEMBL2188684 | 0.77 | KMT2A (0.39) | TRPC6KMT2AALDH1A1GAALMNA | |
| SCHEMBL27679675 | 0.76 | LMNA (0.50) | KMT2AALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL1044671 | 0.74 | KMT2A (0.61) | TRPC6KMT2ANPC1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |