SCHEMBL2188372

SCHEMBL2188372

Cc1ccc(S(N)(=O)=O)c(Cl)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 11/20 0.48
CA1 P00915 11/20 0.48
CA2 P00918 11/20 0.48
CA9 Q16790 10/20 0.48
CA6 P23280 6/20 0.48
CA7 P43166 6/20 0.48
CA5A P35218 5/20 0.48
CA5B Q9Y2D0 5/20 0.48
CA3 P07451 4/20 0.48
CA4 P22748 4/20 0.48
CA14 Q9ULX7 4/20 0.48
PTGES2 Q9H7Z7 5/20 0.48
KDM4E B2RXH2 2/20 0.47
ALDH1A1 P00352 2/20 0.47
CA13 Q8N1Q1 4/20 0.43
CISD1 Q9NZ45 1/20 0.43
POLB P06746 2/20 0.42
MEN1 O00255 1/20 0.42
NPC1 O15118 1/20 0.42
CYP1A2 P05177 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3534066 0.98 CA12 (0.47) CA12CA1CA2CA9CA6
SCHEMBL6063748 0.98 CA12 (0.47) CA12CA1CA2CA9CA6
SCHEMBL13969592 0.83 KDM4E (0.52) CA12CA1CA2CA9CA6
SCHEMBL1200665 0.81 TRPV4 (0.53) CA12CA1CA2CA9PTGES2
SCHEMBL12186139 0.81 L3MBTL1 (0.44) CA1CA2CA9ALDH1A1MEN1
SCHEMBL29907222 0.81 TRPV4 (0.53) CA12CA1CA2CA9PTGES2
SCHEMBL9326968 0.80 KDM4E (0.58) CA12CA1CA2CA9CA6
SCHEMBL841673 0.79 CA2 (0.51) CA12CA1CA2CA9CA6
SCHEMBL30678376 0.79 HSD11B1 (0.39) CA12CA1CA2CA9KDM4E
SCHEMBL30442459 0.79 SMN1; SMN2 (0.39) CA12CA1CA2CA9PTGES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 233 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008065631-A1 METHOD AND COMPOSITION FOR TREATING WATER KATZ JOANNE RAPHAEL (ZA) 2008-06-05 WO claimed
WO-1996014742-A1 SOLID HALOGEN-CONTAINING DISINFECTANT/POLYVINYLCHLORIDE RESIN COMPOSITIONS OLIN CORPORATION (US) 1996-05-23 WO claimed
WO-2024145461-A2 COMPOSITIONS FOR TREATING OSTEOPOROSIS AND BONE LOSS AND METHODS OF USE THEREOF BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-07-04 WO disclosed
EP-4377356-A1 OSMR-SPECIFIC MONOCLONAL ANTIBODIES AND METHODS OF THEIR USE THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-06-05 EP disclosed
US-20240165256-A1 METHODS FOR INCREASING EFFICACY OF IMMUNOCONJUGATES TARGETING ADAM9 FOR THE TREATMENT OF CANCER IMMUNOGEN INC (US) 2024-05-23 US disclosed
EP-4363454-A1 POLYPEPTIDES TARGETING CD70-POSITIVE CANCERS Board of Regents, The University of Texas System (US) 2024-05-08 EP disclosed
EP-4352086-A1 METHODS AND COMPOSITIONS FOR TREATING FIBROSIS The University of Chicago (US) 2024-04-17 EP disclosed
EP-4347643-A1 HUMAN MONOCLONAL ANTIBODIES SPECIFIC TO STREPTOLYSIN O AND METHODS OF USE The United States Government as represented by the Department of Veterans Affairs (US) 2024-04-10 EP disclosed
EP-4326306-A1 METHODS AND COMPOSITIONS COMPRISING MHC CLASS I PEPTIDES Board of Regents, The University of Texas System (US) 2024-02-28 EP disclosed
EP-4320145-A1 METHODS AND COMPOSITIONS COMPRISING MHC CLASS I PEPTIDES Board of Regents, The University of Texas System (US) 2024-02-14 EP disclosed
WO-2023010093-A9 OSMR-SPECIFIC MONOCLONAL ANTIBODIES AND METHODS OF THEIR USE THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-01-25 WO disclosed
EP-1332368-A2 METHODS FOR DETECTING THE EFFICACY OF ANTICANCER TREATMENTS Board of Regents, The University of Texas System (US) 2003-08-06 EP disclosed
WO-2003024993-A2 MEASURING CIRCULATING THERAPEUTIC ANTIBODY, ANTIGEN AND ANTIGEN/ANTIBODY COMPLEXES USING ELISA ASSAYS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2003-03-27 WO disclosed
WO-2002074789-A2 USE OF MONOCLONAL ANTIBODIES AND FUNCTIONAL ASSAYS FOR PREDICTION OF RISK OF OPPORTUNISTIC INFECTION BAYLOR COLLEGE OF MEDICINE (US) 2002-09-26 WO disclosed
WO-2002039121-A2 METHODS FOR DETECTING THE EFFICACY OF ANTICANCER TREATMENTS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2002-05-16 WO disclosed
WO-2002036172-A2 ROTAVIRUS ENTEROTOXIN NSP4 AND METHODS OF USING SAME BAYLOR COLLEGE OF MEDICINE (US) 2002-05-10 WO disclosed
EP-0682257-B1 Methods of detecting collagen degradation in vivo WASHINGTON RES FOUND (US) 1999-04-28 EP disclosed
EP-0890840-A2 Assaying for collagen degradation in vivo Washington Research Foundation (US) 1999-01-13 EP disclosed
EP-0682257-A1 Methods of detecting collagen degradation in vivo Washington Research Foundation (US) 1995-11-15 EP disclosed
EP-0682256-A1 Methods of detecting collagen degradation in vivo Washington Research Foundation (US) 1995-11-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240165256-A1 METHODS FOR INCREASING EFFICACY OF IMMUNOCONJUGATES TARGETING ADAM9 FOR THE TREATMENT OF CANCER ADAM9, TMPRSS15, ADAM17 CA12 100/4885CA1 366/4885CA2 1841/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.