Sugi Predict

Sugi Predict / Compounds / SCHEMBL219001

SCHEMBL219001

SCHEMBL219001

O=Cc1ccc(O)c(F)c1F

nearest known ligand 0.54

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ TRIM24 O15164 2/20 0.44
▸ TRIM33 Q9UPN9 2/20 0.44
▸ ERN1 O75460 9/20 0.43
▸ KDM4E B2RXH2 1/20 0.40
▸ MEN1 O00255 1/20 0.40
▸ NPC1 O15118 1/20 0.40
▸ HSP90AA1 P07900 1/20 0.40
▸ IDO1 P14902 1/20 0.40
▸ RAB9A P51151 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ NPSR1 Q6W5P4 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ TYR P14679 2/20 0.39
▸ CDK1 P06493 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1806887 0.84 TDP1 (0.47) TRIM24TRIM33ERN1KDM4EMEN1
SCHEMBL31306389 0.84 TDP1 (0.47) TRIM24TRIM33ERN1KDM4EMEN1
SCHEMBL31306390 0.84 TDP1 (0.47) TRIM24TRIM33ERN1KDM4EMEN1
SCHEMBL29951860 0.84 ERN1 (0.50) TRIM24TRIM33ERN1KDM4EMEN1
SCHEMBL2333604 0.84 ERN1 (0.50) TRIM24TRIM33ERN1KDM4EMEN1
SCHEMBL31114189 0.84 ERN1 (0.52) TRIM24TRIM33ERN1KDM4EMEN1
SCHEMBL12814036 0.84 ERN1 (0.52) TRIM24TRIM33ERN1KDM4EMEN1
SCHEMBL15195884 0.82 ERN1 (0.50) TRIM24TRIM33ERN1KDM4EMEN1
SCHEMBL20607742 0.80 ERN1 (0.48) TRIM24TRIM33ERN1KDM4EMEN1
SCHEMBL12593983 0.80 ERN1 (0.40) TRIM24TRIM33ERN1KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
EP-4630410-A1 POLQ INHIBITORS Astrazeneca AB (SE) 2025-10-15 — — EP disclosed
US-12424277-B2 Electronic switching device MERCK PATENT GMBH (DE) 2025-09-23 — — US disclosed
US-12414954-B2 POLQ inhibitors ASTRAZENECA AB (SE) 2025-09-16 — — US disclosed
US-20250195530-A1 POLQ INHIBITORS ASTRAZENECA AB (SE) 2025-06-19 — — US disclosed
EP-4062453-B1 ELECTRONIC SWITCHING DEVICE MERCK PATENT GMBH (DE) 2025-06-04 — — EP disclosed
US-12281119-B2 Imidazo[2,1-f][1,2,4]triazin-4-amine derivatives as TLR7 agonist BEIGENE, LTD. (KY) 2025-04-22 — — US disclosed
CN-113454086-B Imidazo [2,1-F ] [1,2,4] triazin-4-amine derivatives as TLR7 agonists 百济神州有限公司 2025-03-14 — — CN disclosed
US-20250011285-A1 CYP11A1 INHIBITORS ORION CORPORATION (FI) 2025-01-09 — — US disclosed
CN-118994022-A Preparation method of 1-methyl-4-phenyl ether derivative and application of non-classical antibacterial activity 中国人民解放军军事科学院军事医学研究院 2024-11-22 — — CN disclosed
US-7381719-B2 Diaryl ethers as opioid receptor antagonist ELI LILLY AND COMPANY (US) 2008-06-03 — — US disclosed
US-7381719-B2 Diaryl ethers as opioid receptor antagonist ELI LILLY AND COMPANY (US) 2008-06-03 — — US disclosed
EP-1562595-B1 DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONISTS LILLY CO ELI (US) 2008-05-21 — — EP disclosed
EP-1562595-B1 DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONISTS LILLY CO ELI (US) 2008-05-21 — — EP disclosed
EP-1615286-B1 Ion conductive polymer electrolyte membrane and production method for the same POLYMATECH CO LTD (JP) 2007-09-12 — — EP disclosed
US-20060217372-A1 Diaryl ethers as opioid receptor antagonist ELI LILLY AND COMPANY 2006-09-28 — — US disclosed
EP-1615286-A1 Ion conductive polymer electrolyte membrane and production method for the same Polymatech Co., Ltd. (JP) 2006-01-11 — — EP disclosed
US-20060004112-A1 Molecular chains of the liquid crystalline polymer (e.g. polybenzoxazole, polybenzothiazole, and polybenzimidazole) having an ionic disosciative group and molecular chain orientated in a specific direction; allows permeation of hydrogen ions generated at a fuel electrode (anode) to cathode POLYMATECH CO., LTD. 2006-01-05 — — US disclosed
EP-1562595-A1 DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY (US) 2005-08-17 — — EP disclosed
WO-2004026305-A1 DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONIST ELI LILLY AND COMPANY (US) 2004-04-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250011285-A1 CYP11A1 INHIBITORS CYP11B1, CYP19A1, CYP11B2 TRIM24 3488/4885TRIM33 3654/4885ERN1 1266/4885
US-12414954-B2 POLQ inhibitors POLQ, POLG, POLB TRIM24 2480/4885TRIM33 3790/4885ERN1 1512/4885
US-12424277-B2 Electronic switching device L1CAM, GRIN2B, NBAS TRIM24 1643/4885TRIM33 1072/4885ERN1 1022/4885
US-20060217372-A1 Diaryl ethers as opioid receptor antagonist OPRM1, OPRL1, OPRD1 TRIM24 2937/4885TRIM33 3733/4885ERN1 873/4885
US-20250195530-A1 POLQ INHIBITORS POLQ, POLG, POLB TRIM24 2480/4885TRIM33 3790/4885ERN1 1512/4885
US-12281119-B2 Imidazo[2,1-f][1,2,4]triazin-4-amine derivatives as TLR7 agonist TLR7, TLR1, TLR3 TRIM24 1232/4885TRIM33 3137/4885ERN1 1758/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.