Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | CASR | P41180 | 1/20 | 0.34 |
| ▸ | S100B | P04271 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11501045 | 0.77 | PYCR1 (0.41) | DHFRCASRSMN1; SMN2MAPK1TDP1 | |
| SCHEMBL21021269 | 0.76 | APP (0.44) | DHFRLMNASMN1; SMN2SIGMAR1PYCR1 | |
| SCHEMBL20749451 | 0.74 | HTR7 (0.41) | DHFRNPC1RAB9AKMT2A | |
| SCHEMBL8611414 | 0.74 | DHFR (0.39) | DHFRCASRMEN1MAPTKMT2A | |
| SCHEMBL15935766 | 0.73 | MAPT (0.47) | S100BNPC1MAPTMAPK1RAB9A | |
| SCHEMBL9313832 | 0.70 | MMP13 (0.34) | MAOAMAOBS100BLMNASMN1; SMN2 | |
| SCHEMBL23899735 | 0.69 | GABRA1 (0.32) | MAOAMAOBLMNASMN1; SMN2MEN1 | |
| SCHEMBL10795320 | 0.68 | PYCR1 (0.56) | DHFRMAPTSIGMAR1PYCR1HTR2A | |
| SCHEMBL15336561 | 0.68 | APP (0.44) | LMNAMEN1NPC1MAPTRAB9A | |
| SCHEMBL11406187 | 0.68 | ALDH1A1 (0.48) | DHFRCASRMEN1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081257-A1 | MODULATORS OF ALPHA-1 ANTITRYPSIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-04-23 | — | — | WO | disclosed |