Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | HTR7 | P34969 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | HPN | P05981 | 1/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.59 |
| ▸ | DRD1 | P21728 | 1/20 | 0.59 |
| ▸ | DRD4 | P21917 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL588394 | 0.87 | SIGMAR1 (0.67) | ALDH1A1KDM4EMAPTHTR7DRD4 | |
| Hydrochloric Acid SCHEMBL587708 | 0.85 | SIGMAR1 (0.65) | ALDH1A1KDM4EHTR7DRD4LMNA | |
| SCHEMBL20415963 | 0.84 | ALDH1A1 (0.83) | ALDH1A1KDM4EMAPTCYP3A4USP2 | |
| SCHEMBL2194377 | 0.80 | HTR7 (0.63) | ALDH1A1KDM4EMAPTHTR7MEN1 | |
| Hydrochloric Acid SCHEMBL9859525 | 0.79 | HTR7 (0.62) | ALDH1A1KDM4EMAPTHTR7MEN1 | |
| SCHEMBL2190477 | 0.79 | LMNA (0.58) | ALDH1A1KDM4EHTR7ADORA3DRD2 | |
| SCHEMBL19145578 | 0.79 | HTR7 (0.81) | ALDH1A1KDM4EMAPTHTR7DRD4 | |
| SCHEMBL4754254 | 0.78 | HTR7 (0.71) | ALDH1A1KDM4EMAPTHTR7CYP2D6 | |
| SCHEMBL1138135 | 0.77 | HTR7 (0.60) | ALDH1A1KDM4EMAPTHTR7DRD2 | |
| SCHEMBL3988740 | 0.76 | HTR7 (0.58) | ALDH1A1KDM4EMAPTHTR7KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040122021-A1 | Enantiomers of 1-[(4-chlorophenyl)phenylmethyl)-4-[(4-methylphenyl)sulfonyl) piperazine | COSSEMENT ERIC (BE) | 2004-06-24 | — | — | US | claimed |
| US-20040122023-A1 | Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl) sulfonyl] piperazine | COSSEMENT ERIC (BE) | 2004-06-24 | — | — | US | claimed |
| EP-0955295-B1 | Therapeutically active levorotatory and dextrorotatory 1-((4-chlorophenyl)phenylmethyl) piperazines | UCB SA (BE) | 2004-05-19 | — | — | EP | claimed |
| US-20030204089-A1 | Enantiomers of 1-[(4-chlorophenyl) phenylmethyl]-4-[(4-methylphenyl) sulfonyl] piperazine | COSSEMENT ERIC (BE) | 2003-10-30 | — | — | US | claimed |
| US-20030013692-A1 | Methods of treating neurological disorders | GULLANS STEVEN R (US) | 2003-01-16 | — | — | US | claimed |
| WO-2002056892-A2 | METHODS OF TREATING NEUROLOGICAL DISORDERS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2002-07-25 | — | — | WO | claimed |
| EP-0955295-A1 | Therapeutically active levorotatory and dextrorotatory 1-((4-chlorophenyl)phenylmethyl) piperazines | UCB, S.A. (BE) | 1999-11-10 | — | — | EP | claimed |
| EP-0617028-A1 | Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulfonyl piperazine | U C B, S.A. (BE) | 1994-09-28 | — | — | EP | claimed |
| WO-2024029173-A1 | AGENT FOR PREVENTING OR AMELIORATING OSTEOPOROSIS | 国立大学法人東海国立大学機構 | 2024-02-08 | — | — | WO | disclosed |
| US-20180208566-A1 | Deuterated Meclizine | CONCERT PHARMACEUTICALS, INC. | 2018-07-26 | — | — | US | disclosed |
| EP-2985024-A1 | THERAPEUTIC AGENT FOR SYSTEMIC BONE DISEASE AND USE THEREOF | National University Corporation Nagoya University (JP) | 2016-02-17 | — | — | EP | disclosed |
| US-20150216860-A1 | THERAPEUTIC AGENT FOR SYSTEMIC BONE DISEASE AND USE THEREOF | NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) | 2015-08-06 | — | — | US | disclosed |
| US-20110172425-A1 | NOVEL WATER BASED PROCESS FOR THE PREPARATION OF SUBSTITUTED DIPHENYLMETHYL PIPERAZINES | CALYX CHEMICALS AND PHARMACEUTICALS PVT. LTD. (IN) | 2011-07-14 | — | — | US | disclosed |
| US-7482022-B2 | Palatable chewable tablet | PFIZER INC. (US) | 2009-01-27 | — | — | US | disclosed |
| EP-0994710-B1 | PHARMACEUTICAL COMPOSITIONS FOR ORAL ADMINISTRATION, COMPRISING A BENZHYDRYLPIPERAZINE AND A CYCLODEXTRIN | UCB SA (BE) | 2002-09-25 | — | — | EP | disclosed |
| US-6436942-B1 | ADMINISTERING THE ANTIHISTAMINE, CETIRIZINE, PRODUCED FROM THIS INTERMEDIATE OF HIGH OPTICAL PURITY | UCB, S.A. (BE) | 2002-08-20 | — | — | US | disclosed |
| EP-0617028-B1 | Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl] piperazine | UCB SA (BE) | 2000-06-14 | — | — | EP | disclosed |
| EP-0955295-A1 | Therapeutically active levorotatory and dextrorotatory 1-((4-chlorophenyl)phenylmethyl) piperazines | UCB, S.A. (BE) | 1999-11-10 | — | — | EP | disclosed |
| US-5478941-A | Useful in treatment of asthma, allergies, inflammation and anxiety; antihistaminic activity | U C B, S.A. (BE) | 1995-12-26 | — | — | US | disclosed |
| EP-0617028-A1 | Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulfonyl piperazine | U C B, S.A. (BE) | 1994-09-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122021-A1 | Enantiomers of 1-[(4-chlorophenyl)phenylmethyl)-4-[(4-methylphenyl)sulfonyl) piperazine | RPLP1, QDPR, RPLP2 | ALDH1A1 224/4885KDM4E 954/4885MAPT 2824/4885 |
| US-20030204089-A1 | Enantiomers of 1-[(4-chlorophenyl) phenylmethyl]-4-[(4-methylphenyl) sulfonyl] piperazine | RPLP1, QDPR, PRLHR | ALDH1A1 187/4885KDM4E 993/4885MAPT 2993/4885 |
| US-20040122023-A1 | Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl) sulfonyl] piperazine | RPLP1, QDPR, PRLHR | ALDH1A1 187/4885KDM4E 993/4885MAPT 2993/4885 |
| US-20180208566-A1 | Deuterated Meclizine | FGFR3, FGFR1, FGFR2 | ALDH1A1 2118/4885KDM4E 3313/4885MAPT 2040/4885 |
| US-20110172425-A1 | NOVEL WATER BASED PROCESS FOR THE PREPARATION OF SUBSTITUTED DIPHENYLMETHYL PIPERAZINES | ALK, WIZ, HACL2 | ALDH1A1 310/4885KDM4E 2018/4885MAPT 4744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.