Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | CNR1 | P21554 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | GHSR | Q92847 | 1/20 | 0.58 |
| ▸ | HTR7 | P34969 | 4/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.51 |
| ▸ | BCL2 | P10415 | 2/20 | 0.50 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL588394 | 0.85 | SIGMAR1 (0.67) | LMNAHTR7SIGMAR1BCL2BAK1 | |
| Hydrochloric Acid SCHEMBL587708 | 0.84 | SIGMAR1 (0.65) | LMNAHTR7SIGMAR1BCL2BAK1 | |
| SCHEMBL2194377 | 0.81 | HTR7 (0.63) | LMNAHTR7BCL2BAK1KDM4E | |
| Hydrochloric Acid SCHEMBL9859525 | 0.80 | HTR7 (0.62) | LMNAHTR7BCL2BAK1KDM4E | |
| SCHEMBL29137691 | 0.79 | BCL2 (0.57) | LMNAHTR7SIGMAR1BCL2BAK1 | |
| SCHEMBL8744976 | 0.79 | KDM4E (0.55) | HTR7SIGMAR1BCL2BAK1KDM4E | |
| SCHEMBL2190696 | 0.79 | ALDH1A1 (0.63) | LMNAADORA3CNR1HRH1OPRK1 | |
| SCHEMBL1138135 | 0.78 | HTR7 (0.60) | LMNAHTR7SIGMAR1BCL2BAK1 | |
| SCHEMBL8744977 | 0.77 | KDM4E (0.57) | HTR7SIGMAR1BCL2BAK1KDM4E | |
| SCHEMBL3988740 | 0.77 | HTR7 (0.58) | LMNAHTR7SIGMAR1BCL2BAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040122021-A1 | Enantiomers of 1-[(4-chlorophenyl)phenylmethyl)-4-[(4-methylphenyl)sulfonyl) piperazine | COSSEMENT ERIC (BE) | 2004-06-24 | — | — | US | claimed |
| EP-0955295-B1 | Therapeutically active levorotatory and dextrorotatory 1-((4-chlorophenyl)phenylmethyl) piperazines | UCB SA (BE) | 2004-05-19 | — | — | EP | claimed |
| US-20030204089-A1 | Enantiomers of 1-[(4-chlorophenyl) phenylmethyl]-4-[(4-methylphenyl) sulfonyl] piperazine | COSSEMENT ERIC (BE) | 2003-10-30 | — | — | US | claimed |
| EP-0955295-A1 | Therapeutically active levorotatory and dextrorotatory 1-((4-chlorophenyl)phenylmethyl) piperazines | UCB, S.A. (BE) | 1999-11-10 | — | — | EP | claimed |
| EP-0617028-A1 | Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulfonyl piperazine | U C B, S.A. (BE) | 1994-09-28 | — | — | EP | claimed |
| US-20110172425-A1 | NOVEL WATER BASED PROCESS FOR THE PREPARATION OF SUBSTITUTED DIPHENYLMETHYL PIPERAZINES | CALYX CHEMICALS AND PHARMACEUTICALS PVT. LTD. (IN) | 2011-07-14 | — | — | US | disclosed |
| WO-2010046908-A2 | NOVEL WATER BASED PROCESS FOR THE PREPARATION OF SUBSTITUTED DIPHENYLMETHYL PIPERAZINES | CALYX CHEMICALS AND PHARMACEUTICALS PVT. LTD. (IN) | 2010-04-29 | — | — | WO | disclosed |
| US-7482022-B2 | Palatable chewable tablet | PFIZER INC. (US) | 2009-01-27 | — | — | US | disclosed |
| EP-1494654-B1 | PALATABLE CHEWABLE TABLET | PFIZER PROD INC (US) | 2008-03-12 | — | — | EP | disclosed |
| US-20070142400-A1 | For treatment of allergies; antihistamines | COSSEMENT ERIC | 2007-06-21 | — | — | US | disclosed |
| US-20060252934-A1 | Enantiomers of 1-[(4-chlorophenyl) phenylmethyl]-4-[(4-methylphenyl) sulfonyl]piperazine | COSSEMENT ERIC | 2006-11-09 | — | — | US | disclosed |
| US-20060229320-A1 | Enantiomers of 1-[(4-chlorophenyl) phenylmethyl]-4-[(4-methylphenyl) sulfonyl] piperazine | GOBERT JEAN | 2006-10-12 | — | — | US | disclosed |
| US-6455533-B1 | SUBSTITUTED BENZHYDRYLPIPERAZINES SUCH AS CETIRIZINE, HYDROXYZINE, EFLETIRIZINE, MECLIZINE AND BUCLIZINE, THE OPTICALLY ACTIVE ISOMERS THEREOF AND THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF. | UCB, S.A. (BE) | 2002-09-24 | — | — | US | disclosed |
| WO-2002067987-A2 | COMBINATIONS OF A 5HT1 RECEPTOR AGONIST WITH AN ANALGESIC, AND AN ANTI-EMETIC AND/OR A GASTROPROKINETIC AGENT | GLAXO GROUP LIMITED (GB) | 2002-09-06 | — | — | WO | disclosed |
| US-6436942-B1 | ADMINISTERING THE ANTIHISTAMINE, CETIRIZINE, PRODUCED FROM THIS INTERMEDIATE OF HIGH OPTICAL PURITY | UCB, S.A. (BE) | 2002-08-20 | — | — | US | disclosed |
| US-20020032217-A1 | PHARMACEUTICAL COMPOSITIONS FOR ORAL ADMINISTRATION, COMPRISING AN ACTIVE SUBSTANCE AND A CYCLODEXTRIN | UCB PHARMA, S.A. (BE) | 2002-03-14 | — | — | US | disclosed |
| EP-0617028-B1 | Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl] piperazine | UCB SA (BE) | 2000-06-14 | — | — | EP | disclosed |
| EP-0955295-A1 | Therapeutically active levorotatory and dextrorotatory 1-((4-chlorophenyl)phenylmethyl) piperazines | UCB, S.A. (BE) | 1999-11-10 | — | — | EP | disclosed |
| US-5478941-A | Useful in treatment of asthma, allergies, inflammation and anxiety; antihistaminic activity | U C B, S.A. (BE) | 1995-12-26 | — | — | US | disclosed |
| EP-0617028-A1 | Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulfonyl piperazine | U C B, S.A. (BE) | 1994-09-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020032217-A1 | PHARMACEUTICAL COMPOSITIONS FOR ORAL ADMINISTRATION, COMPRISING AN ACTIVE SUBSTANCE AND A CYCLODEXTRIN | ABCC5, ABCC2, CYP3A5 | LMNA 4049/4885NR1I2 915/4885ADORA3 1913/4885 |
| US-20040122021-A1 | Enantiomers of 1-[(4-chlorophenyl)phenylmethyl)-4-[(4-methylphenyl)sulfonyl) piperazine | RPLP1, QDPR, RPLP2 | LMNA 4169/4885NR1I2 412/4885ADORA3 3022/4885 |
| US-20030204089-A1 | Enantiomers of 1-[(4-chlorophenyl) phenylmethyl]-4-[(4-methylphenyl) sulfonyl] piperazine | RPLP1, QDPR, PRLHR | LMNA 4245/4885NR1I2 409/4885ADORA3 3022/4885 |
| US-20070142400-A1 | For treatment of allergies; antihistamines | HRH2, HRH1, HRH4 | LMNA 4690/4885NR1I2 892/4885ADORA3 861/4885 |
| US-20110172425-A1 | NOVEL WATER BASED PROCESS FOR THE PREPARATION OF SUBSTITUTED DIPHENYLMETHYL PIPERAZINES | ALK, WIZ, HACL2 | LMNA 2353/4885NR1I2 3318/4885ADORA3 733/4885 |
| US-20060229320-A1 | Enantiomers of 1-[(4-chlorophenyl) phenylmethyl]-4-[(4-methylphenyl) sulfonyl] piperazine | HRH2, CMA1, HRH4 | LMNA 4536/4885NR1I2 951/4885ADORA3 945/4885 |
| US-20060252934-A1 | Enantiomers of 1-[(4-chlorophenyl) phenylmethyl]-4-[(4-methylphenyl) sulfonyl]piperazine | QDPR, PRLHR, COMT | LMNA 4166/4885NR1I2 559/4885ADORA3 2817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.