Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.67 |
| ▸ | PGR | P06401 | 2/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | CNR1 | P21554 | 2/20 | 0.63 |
| ▸ | CNR2 | P34972 | 2/20 | 0.63 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.61 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.59 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | MMP9 | P14780 | 8/20 | 0.55 |
| ▸ | MMP2 | P08253 | 1/20 | 0.55 |
| ▸ | MMP13 | P45452 | 6/20 | 0.55 |
| ▸ | MMP1 | P03956 | 5/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13571459 | 0.84 | PKM (0.67) | LMNAALDH1A1NR3C1PGRNPSR1 | |
| SCHEMBL7674219 | 0.82 | KEAP1 (0.51) | LMNAALDH1A1NR3C1PGRNPSR1 | |
| SCHEMBL7448977 | 0.80 | MMP9 (0.64) | LMNAALDH1A1KEAP1NFE2L2MMP9 | |
| SCHEMBL2121920 | 0.78 | ALDH1A1 (0.76) | LMNAALDH1A1NR3C1PGRNPSR1 | |
| SCHEMBL27511006 | 0.78 | MMP9 (0.75) | MMP9MMP2MMP13MMP1ADAM17 | |
| SCHEMBL27823660 | 0.78 | NR3C1 (0.53) | NR3C1CYP11B1 | |
| SCHEMBL1279470 | 0.77 | PTGES (0.80) | LMNAALDH1A1NR3C1PGRNPSR1 | |
| SCHEMBL1279330 | 0.77 | TAS2R14 (0.74) | LMNAALDH1A1NR3C1PGRNPSR1 | |
| SCHEMBL7319929 | 0.76 | MMP9 (0.68) | KEAP1NFE2L2MMP9MMP2MMP13 | |
| SCHEMBL1169287 | 0.75 | LMNA (0.73) | LMNAALDH1A1NR3C1PGRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519522-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ArQule, Inc. (US) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011082270-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ARQULE. INC. (US) | 2011-07-07 | — | — | WO | disclosed |