Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 2/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | KIF18A | Q8NI77 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27455408 | 0.84 | CRHBP (0.66) | CRHBPCRHR2SMN1; SMN2MAPTGFER | |
| SCHEMBL30954002 | 0.84 | CRHBP (0.66) | CRHBPCRHR2SMN1; SMN2MAPTGFER | |
| SCHEMBL20689407 | 0.81 | CRHBP (0.66) | GRIN2DGRIN3BCHRM1ADRA1DADRA1A | |
| SCHEMBL24215218 | 0.81 | CYP1A2 (0.43) | MAPTKIF18AKMT2A | |
| SCHEMBL21238774 | 0.80 | CRHBP (0.69) | GRIN2DGRIN3BCHRM1ADRA1DADRA1A | |
| SCHEMBL18277835 | 0.78 | GRIN2D (0.57) | GRIN2DGRIN3BCHRM1ADRA1DADRA1A | |
| SCHEMBL22122597 | 0.77 | NOS3 (0.53) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL29481712 | 0.77 | NOS3 (0.53) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL29481713 | 0.77 | NOS3 (0.53) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL30616006 | 0.77 | KIF18A (0.41) | GRIN2DGRIN3BCHRM1ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12637445-B2 | KIF18A inhibitors | AMGEN INC. (US) | 2026-05-26 | — | — | US | disclosed |
| US-20260098029-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2026-04-09 | — | — | US | disclosed |
| US-12509442-B2 | KIF18A inhibitors | AMGEN INC. (US) | 2025-12-30 | — | — | US | disclosed |
| EP-4007756-B1 | KIF18A INHIBITORS | AMGEN INC (US) | 2025-12-24 | — | — | EP | disclosed |
| CN-113226473-B | KIF18A inhibitors | 美国安进公司 | 2025-05-13 | — | — | CN | disclosed |
| CN-119278199-A | Kinesin KIF18A inhibitor and application thereof | 上海湃隆生物科技有限公司 | 2025-01-07 | — | — | CN | disclosed |
| CN-119212988-A | Kinesin KIF18A inhibitor and application thereof | 上海湃隆生物科技有限公司 | 2024-12-27 | — | — | CN | disclosed |
| CN-119072473-A | Condensed ring KIF18A inhibitor compound, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2024-12-03 | — | — | CN | disclosed |
| CN-118922406-A | Synthesis of KIF18A inhibitors | 安进公司 | 2024-11-08 | — | — | CN | disclosed |
| US-20240317715-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2024-09-26 | — | — | US | disclosed |
| EP-4007756-A1 | KIF18A INHIBITORS | Amgen Inc. (US) | 2022-06-08 | — | — | EP | disclosed |
| US-20220106293-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2022-04-07 | — | — | US | disclosed |
| CN-114269731-A | KIF18A inhibitors | 美国安进公司 | 2022-04-01 | — | — | CN | disclosed |
| US-11236069-B2 | KIF18A inhibitors | AMGEN INC. (US) | 2022-02-01 | — | — | US | disclosed |
| US-11236069-B2 | KIF18A inhibitors | AMGEN INC. (US) | 2022-02-01 | — | — | US | disclosed |
| WO-2021026101-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2021-02-11 | — | — | WO | disclosed |
| WO-2021026101-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2021-02-11 | — | — | WO | disclosed |
| US-20200239441-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2020-07-30 | — | — | US | disclosed |
| US-20200239441-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2020-07-30 | — | — | US | disclosed |
| WO-2020132648-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2020-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12509442-B2 | KIF18A inhibitors | KIF18A, KIF18B, KIFC1 | GRIN2D 3549/4885GRIN3B 2882/4885CHRM1 4095/4885 |
| US-20240317715-A1 | KIF18A INHIBITORS | KIF18A, KIF18B, KIF15 | GRIN2D 4134/4885GRIN3B 3652/4885CHRM1 4849/4885 |
| US-20220106293-A1 | KIF18A INHIBITORS | KIF18A, KIF18B, KIF15 | GRIN2D 4134/4885GRIN3B 3652/4885CHRM1 4849/4885 |
| US-12637445-B2 | KIF18A inhibitors | KIF18A, KIF18B, KIF2C | GRIN2D 2513/4885GRIN3B 1354/4885CHRM1 4053/4885 |
| US-20200239441-A1 | KIF18A INHIBITORS | KIF18A, KIF18B, KIF15 | GRIN2D 4134/4885GRIN3B 3652/4885CHRM1 4849/4885 |
| US-20260098029-A1 | KIF18A INHIBITORS | KIF18A, KIF18B, KIFC1 | GRIN2D 3512/4885GRIN3B 2819/4885CHRM1 4189/4885 |
| US-11236069-B2 | KIF18A inhibitors | KIF18A, KIF18B, KIF15 | GRIN2D 4134/4885GRIN3B 3652/4885CHRM1 4849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.