Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9565762 | 0.78 | RIPK1 (0.51) | RIPK1CTSSCTSKHPGDGPR52 | |
| SCHEMBL29836734 | 0.78 | RIPK1 (0.51) | RIPK1CTSSCTSKHPGDGPR52 | |
| SCHEMBL20696571 | 0.74 | GPR52 (0.44) | RIPK1HPGDGPR52PPARGPPARA | |
| SCHEMBL20696564 | 0.74 | TSHR (0.36) | RIPK1CTSSCTSKHPGDGPR52 | |
| SCHEMBL16393647 | 0.72 | RIPK1 (0.47) | RIPK1CTSSCTSKHPGDGPR52 | |
| SCHEMBL5925975 | 0.71 | RIPK1 (0.41) | RIPK1CTSSCTSKHPGDGPR52 | |
| SCHEMBL24140655 | 0.70 | RIPK1 (0.47) | RIPK1CTSSCTSKALDH1A1NPSR1 | |
| SCHEMBL12802659 | 0.69 | RIPK1 (0.49) | RIPK1HPGDPPARATSHRALDH1A1 | |
| SCHEMBL31558898 | 0.68 | APAF1 (0.51) | RIPK1CTSSCTSKHPGDGPR52 | |
| SCHEMBL23189271 | 0.68 | APAF1 (0.51) | RIPK1CTSSCTSKHPGDGPR52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11535640-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2022-12-27 | — | — | US | disclosed |
| EP-3658564-B1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2021-05-19 | — | — | EP | disclosed |
| US-20200207794-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2020-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200207794-A1 | METAL COMPLEXES | IMMT, MCU, SOD1 | RIPK1 2259/4885CTSS 2484/4885CTSK 3241/4885 |
| US-11535640-B2 | Metal complexes | IMMT, MCU, SOD1 | RIPK1 2259/4885CTSS 2484/4885CTSK 3241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.