Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGKA | P23743 | 1/20 | 0.50 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.48 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.48 |
| ▸ | PRKCA | P17252 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.46 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.45 |
| ▸ | LPAR4 | Q99677 | 2/20 | 0.45 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.45 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.45 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | LPAR6 | P43657 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2263737 | 1.00 | DGKA (0.50) | DGKAPRKCEPRKCQPRKCDPRKCA | |
| SCHEMBL2219074 | 0.92 | DGKA (0.51) | DGKAALDH1A1MAPT | |
| SCHEMBL2222768 | 0.92 | DGKA (0.51) | DGKAALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL2221631 | 0.90 | GNAI3 (0.52) | DGKAALDH1A1MAPT | |
| SCHEMBL29255838 | 0.88 | DGKA (0.53) | DGKAPRKCEPRKCQPRKCDPRKCA | |
| SCHEMBL29255816 | 0.88 | DGKA (0.53) | DGKAPRKCEPRKCQPRKCDPRKCA | |
| SCHEMBL5874362 | 0.81 | TERT (0.47) | DGKAMAPTFAAH | |
| SCHEMBL23372759 | 0.80 | SIGMAR1 (0.40) | DGKAALDH1A1 | |
| SCHEMBL4264512 | 0.79 | FAAH (0.51) | ALDH1A1MAPTTHRBCNR1MGLL | |
| SCHEMBL5874706 | 0.78 | ALDH1A1 (0.51) | ALDH1A1MAPTTHRBCNR1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084849-A1 | DIARYLDIAZEPINE PRODRUGS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHOLOGICAL DISORDERS | ALKERMES, INC. (US) | 2011-07-14 | — | — | WO | disclosed |
| WO-2011084846-A1 | QUATERNARY AMMONIUM SALT PRODRUGS | ALKERMES, INC. (US) | 2011-07-14 | — | — | WO | disclosed |