Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | CES2 | O00748 | 3/20 | 0.44 |
| ▸ | CES1 | P23141 | 3/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20400500 | 0.88 | CES2 (0.52) | ALDH1A1MAPK1TDP1TSHRCES2 | |
| SCHEMBL894842 | 0.81 | ALDH1A1 (0.50) | ALDH1A1MAPK1TDP1TSHRCES2 | |
| SCHEMBL9520116 | 0.81 | ALDH1A1 (0.50) | ALDH1A1MAPK1TDP1TSHRCES2 | |
| SCHEMBL15122603 | 0.81 | ALDH1A1 (0.50) | ALDH1A1MAPK1TDP1TSHRCES2 | |
| SCHEMBL28286028 | 0.80 | PTGS1 (0.49) | ALDH1A1MAPK1TDP1CES2CES1 | |
| SCHEMBL6711029 | 0.80 | HPGDS (0.51) | ALDH1A1MAPK1CES2CES1DAO | |
| SCHEMBL1825343 | 0.77 | ESR1 (0.51) | ALDH1A1MAPK1TDP1TSHRCES2 | |
| SCHEMBL1825340 | 0.77 | ESR1 (0.51) | ALDH1A1MAPK1TDP1TSHRCES2 | |
| SCHEMBL12657759 | 0.77 | ESR1 (0.51) | ALDH1A1MAPK1TDP1TSHRCES2 | |
| SCHEMBL9855705 | 0.77 | CES2 (0.44) | CES2CES1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2216312-B1 | PROCESS FOR PRODUCING ORGANIC COMPOUND | M TECHNIQUE CO LTD (JP) | 2019-05-01 | — | — | EP | disclosed |
| CN-104193660-B | Substituted 1,3- diphenyl propane derivatives, their preparation and purposes | 基恩菲特 | 2018-10-19 | — | — | CN | disclosed |
| EP-2371831-B1 | PROCESS FOR PRODUCING ORGANOLITHIUM COMPOUND AND PROCESS FOR PRODUCING SUBSTITUTED AROMATIC COMPOUND | NIPPON SODA CO (JP) | 2016-09-07 | — | — | EP | disclosed |
| US-9133098-B2 | Process for producing organolithium compound and process for producing substituted aromatic compound | NIPPON SODA CO., LTD. (JP) | 2015-09-15 | — | — | US | disclosed |
| US-20150025276-A1 | PROCESS FOR PRODUCING ORGANOLITHIUM COMPOUND AND PROCESS FOR PRODUCING SUBSTITUTED AROMATIC COMPOUND | NIPPON SODA CO., LTD. (JP) | 2015-01-22 | — | — | US | disclosed |
| US-8871970-B2 | Process for producing organolithium compound and process for producing substituted aromatic compound | NIPPON SODA CO., LTD. (JP) | 2014-10-28 | — | — | US | disclosed |
| US-8592498-B2 | Method for producing organic compound and organic compound obtained by the method | M. TECHNIQUE CO., LTD. (JP) | 2013-11-26 | — | — | US | disclosed |
| EP-2371831-A1 | PROCESS FOR PRODUCING ORGANOLITHIUM COMPOUND AND PROCESS FOR PRODUCING SUBSTITUTED AROMATIC COMPOUND | Nippon Soda Co., Ltd. (JP) | 2011-10-05 | — | — | EP | disclosed |
| US-20110224457-A1 | PROCESS FOR PRODUCING ORGANOLITHIUM COMPOUND AND PROCESS FOR PRODUCING SUBSTITUTED AROMATIC COMPOUND | NIPPON SODA CO., LTD. | 2011-09-15 | — | — | US | disclosed |
| US-20110178199-A1 | METHOD FOR PRODUCING ORGANIC COMPOUND AND ORGANIC COMPOUND OBTAINED BY THE METHOD | M. TECHNIQUE CO., LTD. (JP) | 2011-07-21 | — | — | US | disclosed |
| EP-1253152-B1 | METHOD OF CONVERTING FUNCTIONAL GROUP THROUGH HALOGEN-METAL EXCHANGE REACTION | BANYU PHARMA CO LTD (JP) | 2009-11-04 | — | — | EP | disclosed |
| US-7572927-B2 | Method of producing an o-disubstituted aromatic compound, and method of producing a monosubstituted-monohaloaromatic compound | FUJIFILM CORPORATION (JP) | 2009-08-11 | — | — | US | disclosed |
| US-7439535-B2 | Process for exchanging functional groups by halogen-metal exchange reaction | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-10-21 | — | — | US | disclosed |
| US-20080194816-A1 | Method of producing an o-disubstituted aromatic compound, and method of producing a monosubstituted-monohaloaromatic compound | FUJIFILM CORPORATION (JP) | 2008-08-14 | — | — | US | disclosed |
| US-6946559-B2 | Replacing a halogen atom with an electrophilic group (e.g., a formyl group) using either a mixture of an organomagnesium halide and an alkyllithium or a reaction product of the two, such as trialkylmagnesium lithium | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2005-09-20 | — | — | US | disclosed |
| US-20050156336-A1 | Process for exchanging functional groups by halogen-metal exchange reaction | MSD K.K. (JP) | 2005-07-21 | — | — | US | disclosed |
| US-20050104233-A1 | Method of substituent introduction through halogen-metal exchange reaction | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2005-05-19 | — | — | US | disclosed |
| EP-1510510-A1 | METHOD OF SUBSTITUENT INTRODUCTION THROUGH HALOGEN-METAL EXCHANGE REACTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2005-03-02 | — | — | EP | disclosed |
| US-20030130511-A1 | Method of converting functional group through halogen-metal exchange reaction | MSD K.K. (JP) | 2003-07-10 | — | — | US | disclosed |
| EP-1253152-A1 | METHOD OF CONVERTING FUNCTIONAL GROUP THROUGH HALOGEN-METAL EXCHANGE REACTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2002-10-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194816-A1 | Method of producing an o-disubstituted aromatic compound, and method of producing a monosubstituted-monohaloaromatic compound | DDT, OXER1, OSTC | ALDH1A1 1259/4885MAPK1 2478/4885TDP1 4535/4885 |
| US-20050156336-A1 | Process for exchanging functional groups by halogen-metal exchange reaction | SLC39A11, MLX, SLC39A14 | ALDH1A1 4684/4885MAPK1 1780/4885TDP1 4595/4885 |
| US-20050104233-A1 | Method of substituent introduction through halogen-metal exchange reaction | SLC39A11, SLC30A6, SLC39A3 | ALDH1A1 1890/4885MAPK1 3057/4885TDP1 4836/4885 |
| US-20030130511-A1 | Method of converting functional group through halogen-metal exchange reaction | MLX, HAX1, ZFX | ALDH1A1 4406/4885MAPK1 1586/4885TDP1 4526/4885 |
| US-20110178199-A1 | METHOD FOR PRODUCING ORGANIC COMPOUND AND ORGANIC COMPOUND OBTAINED BY THE METHOD | OR10J3, PORCN, ABCG2 | ALDH1A1 3191/4885MAPK1 3660/4885TDP1 1880/4885 |
| US-20110224457-A1 | PROCESS FOR PRODUCING ORGANOLITHIUM COMPOUND AND PROCESS FOR PRODUCING SUBSTITUTED AROMATIC COMPOUND | C9, TRPA1, PKD1 | ALDH1A1 4118/4885MAPK1 2260/4885TDP1 4590/4885 |
| US-20150025276-A1 | PROCESS FOR PRODUCING ORGANOLITHIUM COMPOUND AND PROCESS FOR PRODUCING SUBSTITUTED AROMATIC COMPOUND | C9, TRPA1, PKD1 | ALDH1A1 4118/4885MAPK1 2260/4885TDP1 4590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.