Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | CES2 | O00748 | 3/20 | 0.44 |
| ▸ | CES1 | P23141 | 3/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15122603 | 1.00 | ALDH1A1 (0.50) | ALDH1A1TDP1MAPK1TSHRCES2 | |
| SCHEMBL9520116 | 1.00 | ALDH1A1 (0.50) | ALDH1A1TDP1MAPK1TSHRCES2 | |
| SCHEMBL11462823 | 0.81 | ALDH1A1 (0.48) | ALDH1A1TSHRESR1MEN1KMT2A | |
| SCHEMBL11462824 | 0.81 | ALDH1A1 (0.48) | ALDH1A1TSHRESR1MEN1KMT2A | |
| SCHEMBL7855650 | 0.81 | ALDH1A1 (0.50) | ALDH1A1TDP1MAPK1TSHRCES2 | |
| SCHEMBL2222239 | 0.81 | ALDH1A1 (0.50) | ALDH1A1TDP1MAPK1TSHRCES2 | |
| SCHEMBL27469663 | 0.79 | ALDH1A1 (0.48) | ALDH1A1TDP1MAPK1TSHRCES2 | |
| SCHEMBL12657759 | 0.77 | ESR1 (0.51) | ALDH1A1TDP1MAPK1TSHRCES2 | |
| SCHEMBL1825340 | 0.77 | ESR1 (0.51) | ALDH1A1TDP1MAPK1TSHRCES2 | |
| SCHEMBL1825343 | 0.77 | ESR1 (0.51) | ALDH1A1TDP1MAPK1TSHRCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150299196-A1 | Flindersia Alkaloids, Derivatives and Analogs: Compositions and Methods for Producing the Same | UNIVERSITY OF HOUSTON SYSTEM (US) | 2015-10-22 | — | — | US | claimed |
| US-9067946-B2 | Flindersia alkaloids, derivatives and analogs: compositions and methods for producing the same | UNIVERSITY OF HOUSTON SYSTEM (US) | 2015-06-30 | — | — | US | claimed |
| WO-2013109866-A1 | FLINDERSIA ALKALOIDS, DERIVATIVES AND ANALOGS: COMPOSITIONS AND METHODS FOR PRODUCING THE SAME | UNIVERSITY OF HOUSTON SYSTEM (US) | 2013-07-25 | — | — | WO | claimed |
| US-20130190511-A1 | Flindersia Alkaloids, Derivatives and Analogs: Compositions and Methods for Producing the Same | HOUSTON SYSTEM, UNIVERSITY OF | 2013-07-25 | — | — | US | claimed |
| US-5565328-A | COLORIMETRIC ANALYSIS WITH FLUOROMETRIC READER USING SUITABLE FLUOROPHORE | DADE INTERNATIONAL INC. (US) | 1996-10-15 | — | — | US | claimed |
| WO-2024190912-A1 | METHOD FOR SUPPRESSING VITAMIN ODOR | 味の素株式会社 | 2024-09-19 | — | — | WO | disclosed |
| US-11389464-B2 | Arginase inhibitors as therapeutics | MARS, INCORPORATED (US) | 2022-07-19 | — | — | US | disclosed |
| EP-3719024-A1 | ARGINASE INHIBITORS AS THERAPEUTICS | Mars, Incorporated (US) | 2020-10-07 | — | — | EP | disclosed |
| US-20200246362-A1 | Arginase Inhibitors as Therapeutics | MARS, INCORPORATED | 2020-08-06 | — | — | US | disclosed |
| CN-106008569-B9 | Borate as arginase inhibitor and composition and application thereof | 马尔斯公司 | 2020-05-22 | — | — | CN | disclosed |
| EP-3034509-B1 | ARGINASE INHIBITORS AS THERAPEUTICS | MARS INC (US) | 2020-04-22 | — | — | EP | disclosed |
| CN-106008569-B | Borate as arginase inhibitor and composition and application thereof | 马尔斯公司 | 2020-04-03 | — | — | CN | disclosed |
| US-5888760-A | COMBINATION OF NON-REDUNDANT TESTS IN REACTION CHAMBERS CONTAINING SUBSTRATES FOR ENZYMATIC CLASSIFICATION BY DETECTION OF FLUORESCENT OR COLORIMETRIC PRODUCTS FORMED | DADE MICROSCAN INC. (US) | 1999-03-30 | — | — | US | disclosed |
| WO-1998045469-A1 | UNIVERSAL TEST SYSTEMS AND METHODS OF USE THEREOF FOR IDENTIFYING MULTIPLE FAMILIES OF MICROORGANISMS | DADE MICROSCAN INC. (US) | 1998-10-15 | — | — | WO | disclosed |
| EP-0254578-B1 | ANTIBIOTIC INTERMEDIATES | ELI LILLY AND COMPANY (US) | 1993-09-08 | — | — | EP | disclosed |
| EP-0480242-A2 | Method for the production of alpha,beta-unsaturated carbonyl compounds | BASF Aktiengesellschaft (DE) | 1992-04-15 | — | — | EP | disclosed |
| US-4772694-A | Chiral 3-(1,2,5-trisubstituted imidazolidinone) azetidinone antibiotic intermediates | ELI LILLY AND COMPANY (US) | 1988-09-20 | — | — | US | disclosed |
| EP-0254578-A1 | Antibiotic intermediates | ELI LILLY AND COMPANY (US) | 1988-01-27 | — | — | EP | disclosed |
| US-4087549-A | Sulphonic acid containing indenyl derivatives | MERCK & CO., INC. (US) | 1978-05-02 | — | — | US | disclosed |
| US-3716336-A | METHOD FOR DETERMINING PROCAINAMIDE LEVELS IN BLOOD OR URINE | SQUIBB & SONS INC | 1973-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11389464-B2 | Arginase inhibitors as therapeutics | ARG1, ARG2, PRMT1 | ALDH1A1 1448/4885TDP1 1099/4885MAPK1 2804/4885 |
| US-20130190511-A1 | Flindersia Alkaloids, Derivatives and Analogs: Compositions and Methods for Producing the Same | NAAA, MAOA, AANAT | ALDH1A1 2072/4885TDP1 904/4885MAPK1 2407/4885 |
| US-20200246362-A1 | Arginase Inhibitors as Therapeutics | ARG1, ARG2, PRMT1 | ALDH1A1 1448/4885TDP1 1099/4885MAPK1 2804/4885 |
| US-20150299196-A1 | Flindersia Alkaloids, Derivatives and Analogs: Compositions and Methods for Producing the Same | MAOA, NAAA, FLNA | ALDH1A1 2383/4885TDP1 795/4885MAPK1 2577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.