Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9723025 | 0.85 | DRD2 (0.68) | DRD2DRD3MEN1KMT2AOPRM1 | |
| SCHEMBL30822482 | 0.81 | ADRA2C (0.66) | MEN1KMT2AOPRM1MAPTADRA2C | |
| SCHEMBL10244469 | 0.81 | ADRB1 (0.59) | MAPTHTR7ALDH1A1LMNAGAA | |
| SCHEMBL29566812 | 0.80 | DRD2 (0.68) | DRD2DRD3MEN1KMT2AOPRM1 | |
| SCHEMBL1039861 | 0.80 | DRD2 (0.68) | DRD2DRD3MEN1KMT2AOPRM1 | |
| SCHEMBL15534827 | 0.80 | HTR3A (0.50) | DRD2DRD3MAPTHTR7ALDH1A1 | |
| SCHEMBL10294019 | 0.79 | HTR3E (0.58) | MAPTHTR7ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3866217 | 0.79 | DHFR (0.47) | MEN1KMT2AMAPTADRA2CHTR7 | |
| SCHEMBL117340 | 0.79 | ALDH1A1 (0.45) | MAPTADRA2CALDH1A1LMNAGAA | |
| Bromide SCHEMBL4507734 | 0.79 | DRD2 (0.66) | DRD2DRD3MEN1KMT2AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2544535-A1 | PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE | North Carolina Central University (US) | 2013-01-16 | — | — | EP | claimed |
| WO-2011112858-A1 | PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 2011-09-15 | — | — | WO | claimed |
| WO-2011084503-A1 | PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 2011-07-14 | — | — | WO | disclosed |
| EP-1750727-A2 | KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005117909-A2 | KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-12-15 | — | — | WO | disclosed |