Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | HTR6 | P50406 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | STAT6 | P42226 | 1/20 | 0.49 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22235940 | 0.88 | EGFR (0.65) | EGFRHTR6NPC1RAB9ASTAT6 | |
| SCHEMBL22258556 | 0.77 | TRPV1 (0.41) | RAB9ASTAT6MAPK1KMT2AMEN1 | |
| SCHEMBL22258557 | 0.77 | STAT6 (0.41) | RAB9ASTAT6MAPK1KMT2AMEN1 | |
| SCHEMBL22258475 | 0.75 | NPC1 (0.49) | NPC1RAB9AGAAMAPTMAPK1 | |
| SCHEMBL22258246 | 0.74 | NOS1 (0.40) | NPC1RAB9AMAPTJAK1JAK3 | |
| SCHEMBL22258247 | 0.74 | CDK5 (0.49) | — | |
| SCHEMBL22258553 | 0.74 | HSD17B10 (0.40) | — | |
| SCHEMBL22258547 | 0.74 | LTA4H (0.39) | STAT6GAA | |
| SCHEMBL22258549 | 0.73 | LTA4H (0.47) | NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL22258491 | 0.73 | RAB9A (0.37) | NPC1RAB9AMAPTFLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |