SCHEMBL2229037

SCHEMBL2229037

O=S(=O)(NOc1ccccc1)c1cccs1

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.51
CYP2C9 P11712 1/20 0.51
CYP2C19 P33261 1/20 0.51
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
HTR1A P08908 1/20 0.48
DRD2 P14416 1/20 0.48
HTR7 P34969 1/20 0.48
HTR6 P50406 1/20 0.48
HTT P42858 1/20 0.48
ALDH1A1 P00352 4/20 0.48
TP53 P04637 1/20 0.48
KDM4E B2RXH2 1/20 0.46
NPC1 O15118 1/20 0.44
HPGD P15428 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7571190 0.77 CYP2D6 (0.62) CYP2D6CYP2C9CYP2C19MEN1KMT2A
SCHEMBL9231998 0.74 PGR (0.52) MEN1KMT2AHTR6ALDH1A1KDM4E
SCHEMBL24254325 0.73 CYP2D6 (0.67) CYP2D6CYP2C9CYP2C19MEN1KMT2A
SCHEMBL4709087 0.73 MEN1 (0.84) CYP2D6CYP2C9CYP2C19MEN1KMT2A
SCHEMBL8794822 0.73 RAB9A (0.47) CYP2D6CYP2C9CYP2C19MEN1KMT2A
SCHEMBL4707300 0.71 MEN1 (0.61) CYP2D6CYP2C9CYP2C19MEN1KMT2A
SCHEMBL11198231 0.71 RAB9A (0.46) CYP2D6CYP2C9CYP2C19MEN1KMT2A
SCHEMBL7594332 0.71 ALDH1A1 (0.71) CYP2D6CYP2C9CYP2C19MEN1KMT2A
SCHEMBL4433902 0.70 CYP2D6 (0.62) CYP2D6CYP2C9CYP2C19MEN1KMT2A
SCHEMBL8232303 0.70 CYP2D6 (0.62) CYP2D6CYP2C9CYP2C19MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210087163-A1 PHENOXY THIOPHENE SULFONAMIDES AND OTHER COMPOUNDS FOR USE AS INHIBITORS OF BACTERIAL GLUCURONIDASE NORTH CAROLINA CENTRAL UNIVERSITY (US) 2021-03-25 US claimed
EP-2544535-B1 PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE NORTH CAROLINA CENTRAL UNIV (US) 2017-04-19 EP claimed
US-20160237058-A1 PHENOXY THIOPHENE SULFONAMIDES AND OTHER COMPOUNDS FOR USE AS INHIBITORS OF BACTERIAL GLUCURONIDASE NORTH CAROLINA CENTRAL UNIVERSITY (US) 2016-08-18 US claimed
US-20130345235-A1 PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2013-12-26 US claimed
US-20130345196-A1 PHENOXY THIOPHENE SULFONAMIDES AND OTHER COMPOUNDS FOR USE AS INHIBITORS OF BACTERIAL GLUCURONIDASE THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL 2013-12-26 US claimed
EP-2544535-A1 PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE North Carolina Central University (US) 2013-01-16 EP claimed
WO-2011112858-A1 PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE NORTH CAROLINA CENTRAL UNIVERSITY (US) 2011-09-15 WO claimed
WO-2011084503-A1 PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES NORTH CAROLINA CENTRAL UNIVERSITY (US) 2011-07-14 WO claimed
EP-3662751-B1 PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF B-GLUCURONIDASE UNIV KAOHSIUNG MEDICAL (TW) 2021-10-13 EP disclosed
US-11135206-B2 Pyrazolo[4,3-c]quinoline derivatives for inhibition of β-glucuronidase KAOHSIUNG MEDICAL UNIVERSITY (TW) 2021-10-05 US disclosed
US-11052072-B2 Pyrazolo[4,3-C] quinoline derivatives for inhibition of β-glucuronidase KAOHSIUNG MEDICAL UNIVERSITY (TW) 2021-07-06 US disclosed
US-20210087163-A1 PHENOXY THIOPHENE SULFONAMIDES AND OTHER COMPOUNDS FOR USE AS INHIBITORS OF BACTERIAL GLUCURONIDASE NORTH CAROLINA CENTRAL UNIVERSITY (US) 2021-03-25 US disclosed
US-20210087163-A1 PHENOXY THIOPHENE SULFONAMIDES AND OTHER COMPOUNDS FOR USE AS INHIBITORS OF BACTERIAL GLUCURONIDASE NORTH CAROLINA CENTRAL UNIVERSITY (US) 2021-03-25 US disclosed
EP-3662751-A1 PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF B-GLUCURONIDASE Kaohsiung Medical University (TW) 2020-06-10 EP disclosed
EP-2544535-A1 PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE North Carolina Central University (US) 2013-01-16 EP disclosed
EP-2544535-A1 PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE North Carolina Central University (US) 2013-01-16 EP disclosed
WO-2011112858-A1 PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE NORTH CAROLINA CENTRAL UNIVERSITY (US) 2011-09-15 WO disclosed
WO-2011112858-A1 PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE NORTH CAROLINA CENTRAL UNIVERSITY (US) 2011-09-15 WO disclosed
WO-2011084503-A1 PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES NORTH CAROLINA CENTRAL UNIVERSITY (US) 2011-07-14 WO disclosed
US-6331637-B1 N-Alkyl, N-Alkenyl, N-Alkynyl, N-Aryl and N-fused bicyclo or tricyclo thienyl-, furyl-,and Pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin TEXAS BIOTECHNOLOGY CORPORATION 2001-12-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130345235-A1 PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE CES2, TOP1, GUSB CYP2D6 302/4885CYP2C9 155/4885CYP2C19 431/4885
US-20160237058-A1 PHENOXY THIOPHENE SULFONAMIDES AND OTHER COMPOUNDS FOR USE AS INHIBITORS OF BACTERIAL GLUCURONIDASE TOP2A, TOP1, PNP CYP2D6 132/4885CYP2C9 156/4885CYP2C19 303/4885
US-20130345196-A1 PHENOXY THIOPHENE SULFONAMIDES AND OTHER COMPOUNDS FOR USE AS INHIBITORS OF BACTERIAL GLUCURONIDASE TOP2A, TOP1, TOP2B CYP2D6 129/4885CYP2C9 140/4885CYP2C19 267/4885
US-11052072-B2 Pyrazolo[4,3-C] quinoline derivatives for inhibition of β-glucuronidase UGT1A3, UGT1A1, DPP3 CYP2D6 244/4885CYP2C9 598/4885CYP2C19 202/4885
US-20210087163-A1 PHENOXY THIOPHENE SULFONAMIDES AND OTHER COMPOUNDS FOR USE AS INHIBITORS OF BACTERIAL GLUCURONIDASE TOP2A, TOP1, PNP CYP2D6 132/4885CYP2C9 156/4885CYP2C19 303/4885
US-11135206-B2 Pyrazolo[4,3-c]quinoline derivatives for inhibition of β-glucuronidase UGT1A3, UGT1A1, DPP3 CYP2D6 244/4885CYP2C9 598/4885CYP2C19 202/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.