Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.34 |
| ▸ | CPB1 | P15086 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6239442 | 1.00 | POLB (0.41) | POLBMAPK1GAAHIF1ACYP2D6 | |
| SCHEMBL2980934 | 0.88 | CPB2 (0.38) | AKR1B1CPB2CPB1 | |
| SCHEMBL7345574 | 0.87 | KDM4E (0.43) | POLBGAAALDH1A1HPGDKDM4E | |
| SCHEMBL6240988 | 0.86 | POLB (0.38) | POLBMAPK1GAAHIF1AKDM4E | |
| SCHEMBL466340 | 0.85 | GAA (0.40) | POLBGAAALDH1A1 | |
| SCHEMBL466341 | 0.85 | GAA (0.40) | POLBGAAALDH1A1 | |
| SCHEMBL1643961 | 0.85 | GAA (0.40) | POLBGAAALDH1A1 | |
| SCHEMBL31711243 | 0.83 | ALDH1A1 (0.46) | POLBALDH1A1KDM4E | |
| SCHEMBL28558505 | 0.83 | CPB2 (0.38) | ALDH1A1CPB2CPB1 | |
| SCHEMBL147911 | 0.83 | CPB2 (0.38) | ALDH1A1CPB2CPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119462458-A | Covalent inhibitor of targeted hCES A and preparation method and application thereof | 中国人民解放军海军军医大学 | 2025-02-18 | — | — | CN | disclosed |
| WO-2024009289-A2 | METAL ORGANIC FRAMEWORK MATERIALS AND APPLICATION THEREOF IN ELECTROCATALYSIS | KING KHALID UNIVERSITY (SA) | 2024-01-11 | — | — | WO | disclosed |
| US-8623661-B2 | Iron chelating agent, method for producing same, method for determining amount of iron ions and method for trapping iron ions | NATIONAL UNIVERSITY CORPORATION ASAHIKAWA MEDICAL COLLEGE (JP) | 2014-01-07 | — | — | US | disclosed |
| US-8623661-B2 | Iron chelating agent, method for producing same, method for determining amount of iron ions and method for trapping iron ions | NATIONAL UNIVERSITY CORPORATION ASAHIKAWA MEDICAL COLLEGE (JP) | 2014-01-07 | — | — | US | disclosed |
| US-20110189779-A1 | IRON CHELATING AGENT, METHOD FOR PRODUCING SAME, METHOD FOR DETERMINING AMOUNT OF IRON IONS AND METHOD FOR TRAPPING IRON IONS | YAMAGATA UNIVERSITY (JP) | 2011-08-04 | — | — | US | disclosed |
| US-20110189779-A1 | IRON CHELATING AGENT, METHOD FOR PRODUCING SAME, METHOD FOR DETERMINING AMOUNT OF IRON IONS AND METHOD FOR TRAPPING IRON IONS | YAMAGATA UNIVERSITY (JP) | 2011-08-04 | — | — | US | disclosed |
| EP-2341774-A1 | TREATMENT OF NEUROBLASTOMA WITH MULTI-ARM POLYMERIC CONJUGATES OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN | Enzon Pharmaceuticals, Inc. (US) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010048018-A1 | TREATMENT OF NEUROBLASTOMA WITH MULTI-ARM POLYMERIC CONJUGATES OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN | ENZON PHARMACEUTICALS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010025337-A1 | METHOD OF TREATING RAS ASSOCIATED CANCER | ENZON PHARMACEUTICALS, INC. (US) | 2010-03-04 | — | — | WO | disclosed |
| EP-2073809-A2 | TREATMENT OF NON-HODGKIN'S LYMPHOMAS WITH MULTI-ARM POLYMERIC CONJUGATES OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN | Enzon Pharmaceuticals, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009060218-A1 | NOVEL COMPLEXES AND A PROCESS FOR THEIR PREPARATION | POLYTHERICS LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |
| EP-1996208-A2 | MULTI-ARM POLYMERIC CONJUGATES OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN FOR TREATMENT OF BREAST, COLORECTAL, PANCREATIC, OVARIAN AND LUNG CANCERS | Enzon Pharmaceuticals, Inc. (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2008033643-A2 | TREATMENT OF NON-HODGKIN'S LYMPHOMAS WITH MULTI-ARM POLYMERIC CONJUGATES OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN | ENZON PHARMACEUTICALS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |
| EP-1846412-A1 | PROCESS FOR THE MANUFACTURING OF 7-ETHYL-10-HYDROXY CAMPTOTHECIN | Fermion Oy (FI) | 2007-10-24 | — | — | EP | disclosed |
| WO-2007092646-A2 | MULTI-ARM POLYMERIC CONJUGATES OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN FOR TREATMENT OF BREAST, COLORECTAL, PANCREATIC, OVARIAN AND LUNG CANCERS | ENZON PHARMACEUTICALS, INC. (US) | 2007-08-16 | — | — | WO | disclosed |
| WO-2006082279-A1 | PROCESS FOR THE MANUFACTURING OF 7-ETHYL-10-HYDROXY CAMPTOTHECIN | FERMION OY (FI) | 2006-08-10 | — | — | WO | disclosed |
| EP-1019090-A1 | POLYMERIC DERIVATIVES OF CAMPTOTHECINS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999017804-A1 | POLYMERIC DERIVATIVES OF CAMPTOTHECINS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110189779-A1 | IRON CHELATING AGENT, METHOD FOR PRODUCING SAME, METHOD FOR DETERMINING AMOUNT OF IRON IONS AND METHOD FOR TRAPPING IRON IONS | SLC40A1, FTH1, TFRC | POLB 3330/4885MAPK1 4652/4885GAA 2435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.