Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.42 |
| ▸ | APLNR | P35414 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | PARL | Q9H300 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.39 |
| ▸ | CA2 | P00918 | 4/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.39 |
| ▸ | CA3 | P07451 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.39 |
| ▸ | CA6 | P23280 | 2/20 | 0.39 |
| ▸ | CA5A | P35218 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22308629 | 0.81 | AKR1B1 (0.44) | KMT2ACA1CA2CA9CA4 | |
| SCHEMBL22308264 | 0.81 | AKR1B1 (0.44) | KMT2AHSP90AA1CXCR5APLNRRAB9A | |
| SCHEMBL22307381 | 0.81 | AKR1B1 (0.41) | AGTR1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL22308428 | 0.78 | ALDH1A1 (0.43) | KMT2ARAB9AGFERCA1CA2 | |
| SCHEMBL22307873 | 0.78 | MAOA (0.40) | CA1CA2CA12CA9CA13 | |
| SCHEMBL22307869 | 0.75 | MAPT (0.44) | KMT2ARAB9AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL22308350 | 0.75 | ALDH3A1 (0.34) | KMT2AGFERCA1CA2LMNA | |
| SCHEMBL22308352 | 0.69 | NR1I2 (0.39) | CA1CA2CA12CA9ALDH1A1 | |
| SCHEMBL11419996 | 0.69 | CA2 (0.67) | AGTR1KMT2APARLCA1CA2 | |
| SCHEMBL11855965 | 0.69 | CA2 (0.67) | AGTR1KMT2APARLCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358940-B2 | K-Ras modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-06-14 | — | — | US | disclosed |
| US-20200247762-A1 | K-RAS MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247762-A1 | K-RAS MODULATORS | KRAS, HRAS, NRAS | AGTR1 1228/4885KMT2A 1071/4885HSP90AA1 1051/4885 |
| US-11358940-B2 | K-Ras modulators | KRAS, HRAS, NRAS | AGTR1 1735/4885KMT2A 2210/4885HSP90AA1 550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.