Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL672196 | 0.97 | NFKB1 (0.33) | NFKB1SLC9A1PTGS1 | |
| Potassium Ion SCHEMBL9246627 | 0.86 | ALDH1A1 (0.30) | — | |
| SCHEMBL13836247 | 0.83 | ALDH1A1 (0.30) | — | |
| Lithium Ion SCHEMBL2469320 | 0.83 | ALDH1A1 (0.30) | — | |
| SCHEMBL13835464 | 0.83 | ALDH1A1 (0.30) | — | |
| Potassium Ion SCHEMBL8338015 | 0.81 | CA1 (0.38) | — | |
| SCHEMBL4353636 | 0.76 | KDM4E (0.37) | — | |
| SCHEMBL5697529 | 0.73 | ALDH1A1 (0.35) | NFKB1 | |
| SCHEMBL3337730 | 0.72 | CA1 (0.32) | — | |
| SCHEMBL30134652 | 0.71 | TDP1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103649170-B | Sulfopolyester polymer compositions with improved water dispersibility | 伊士曼化工公司 | 2016-11-23 | — | — | CN | disclosed |
| CN-105461909-A | Sulfopolyester polymer compositions with improved water dispersibility | EASTMAN CHEM CO | 2016-04-06 | — | — | CN | disclosed |
| CN-103649170-A | Sulfopolyester polymer compositions with improved water dispersibility | EASTMAN CHEM CO | 2014-03-19 | — | — | CN | disclosed |
| WO-2011085058-A1 | POLYLACTIDE MOLDING COMPOSITIONS AND MOLDING PROCESS | NATURE WORKS LLC (US) | 2011-07-14 | — | — | WO | disclosed |