Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.34 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.34 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HMGCR | P04035 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | SLC13A5 | Q86YT5 | 5/20 | 0.34 |
| ▸ | ACLY | P53396 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CPT2 | P23786 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL1261063 | 0.98 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNATSHRMAPT | |
| SCHEMBL235941 | 0.98 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNATSHRMAPT | |
| SCHEMBL29137169 | 0.96 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNATSHRMAPT | |
| SCHEMBL21815387 | 0.96 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNATSHRMAPT | |
| SCHEMBL8813391 | 0.96 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Ammonia Solution, Strong SCHEMBL655552 | 0.96 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Iodide SCHEMBL8406735 | 0.96 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNATSHRMAPT | |
| SCHEMBL9815615 | 0.96 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNATSHRMAPT | |
| SCHEMBL28070648 | 0.96 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNATSHRMAPT | |
| SCHEMBL28275314 | 0.96 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNATSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2025318-B1 | Two-phase composition for conditioning hair | KAO GERMANY GMBH (DE) | 2018-07-25 | — | — | EP | disclosed |
| US-8715633-B2 | Composition for keratin fibres | KAO GERMANY GMBH (DE) | 2014-05-06 | — | — | US | disclosed |
| EP-1911435-B1 | Two-phase composition for improving curl retention | KAO GERMANY GMBH (DE) | 2013-07-24 | — | — | EP | disclosed |
| US-20120103357-A1 | COMPOSITION FOR KERATIN FIBRES | KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) | 2012-05-03 | — | — | US | disclosed |
| US-20110192413-A1 | Two-Phase Composition for Improving Curl Retention | KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) | 2011-08-11 | — | — | US | disclosed |
| US-20090286104-A1 | MULTI-LAYERED NICKEL-PHOSPHOROUS COATINGS AND PROCESSES FOR FORMING THE SAME | GENERAL ELECTRIC COMPANY (US) | 2009-11-19 | — | — | US | disclosed |
| EP-1927335-B1 | Two-phase conditioning composition | KPSS KAO GMBH (DE) | 2009-10-21 | — | — | EP | disclosed |
| US-20090098077-A1 | Two-Phase Composition for Improving Curl Retention | KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) | 2009-04-16 | — | — | US | disclosed |
| EP-2036534-A1 | Multi phase composition for conditioning hair | KPSS-Kao Professional Salon Services GmbH (DE) | 2009-03-18 | — | — | EP | disclosed |
| EP-2025317-A1 | Two or multi phase composition for conditioning hair | KPSS-Kao Professional Salon Services GmbH (DE) | 2009-02-18 | — | — | EP | disclosed |
| EP-2022465-A1 | Multi-phase composition for conditioning hair | KPSS-Kao Professional Salon Services GmbH (DE) | 2009-02-11 | — | — | EP | disclosed |
| CN-100408202-C | Electroless plating solution and process | MATTSON TECH INC (US) | 2008-08-06 | — | — | CN | disclosed |
| EP-1927335-A1 | Two-phase conditioning composition | KPSS-Kao Professional Salon Services GmbH (DE) | 2008-06-04 | — | — | EP | disclosed |
| US-20080124293-A1 | COMPOSITION FOR KERATIN FIBRES | KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) | 2008-05-29 | — | — | US | disclosed |
| EP-1925280-A1 | Two-phase conditioning composition | KPSS-Kao Professional Salon Services GmbH (DE) | 2008-05-28 | — | — | EP | disclosed |
| EP-1911435-A1 | Two-phase composition for improving curl retention | KPSS-Kao Professional Salon Services GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| CN-1761534-A | Electroless plating solution and method | MATTSON TECH INC (US) | 2006-04-19 | — | — | CN | disclosed |
| US-20050009922-A1 | Stable aqueous antimicrobial suspension | CARLSON PAUL E (US) | 2005-01-13 | — | — | US | disclosed |
| US-6797312-B2 | DOES NOT REQUIRE THE USE OF A CATALYST, COMPRISING A FIRST REDUCING AGENT, A SECOND REDUCING AGENT, A PH ADJUSTING AGENT, A FIRST METAL SOURCE, AND A SECOND METAL SOURCE | MATTSON TECHNOLOGY, INC. | 2004-09-28 | — | — | US | disclosed |
| US-20040142114-A1 | Electroless plating solution and process | MATTSON TECHNOLOGY, INC. | 2004-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110192413-A1 | Two-Phase Composition for Improving Curl Retention | CCRL2, TIPRL, ASH2L | CHRM1 1777/4885ADRA1A 3762/4885MEN1 2608/4885 |
| US-20080124293-A1 | COMPOSITION FOR KERATIN FIBRES | KRT18, MICA, CUTA | CHRM1 2013/4885ADRA1A 4850/4885MEN1 571/4885 |
| US-20120103357-A1 | COMPOSITION FOR KERATIN FIBRES | KRT18, MICA, CUTA | CHRM1 2013/4885ADRA1A 4850/4885MEN1 571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.