Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848969 | 0.92 | KDM4E (0.47) | ALDH1A1L3MBTL1TSHRKMT2AHPGD | |
| SCHEMBL2240565 | 0.88 | HPGD (0.44) | ALDH1A1KMT2APOLBHPGDLMNA | |
| SCHEMBL19709882 | 0.86 | MAOB (0.48) | ALDH1A1TDP1L3MBTL1KMT2AHPGD | |
| SCHEMBL16789591 | 0.85 | GLRA1 (0.47) | ALDH1A1TSHRKMT2APOLBHPGD | |
| SCHEMBL6865219 | 0.84 | TDP1 (0.54) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL6865199 | 0.83 | HPGD (0.38) | ALDH1A1TSHRKMT2APOLBHPGD | |
| SCHEMBL8333370 | 0.80 | LIPG (0.47) | ALDH1A1L3MBTL1TSHRKMT2ARAB9A | |
| SCHEMBL16789584 | 0.80 | ALDH1A1 (0.64) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL31354660 | 0.80 | ALDH1A1 (0.64) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL6858810 | 0.79 | LIPG (0.47) | ALDH1A1KMT2ARAB9AHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10682430-B2 | Alpha-emitting complexes | BAYER AS (NO) | 2020-06-16 | — | — | US | disclosed |
| EP-3417883-B1 | TARGETED ALPHA-PARTICLE EMITTING COMPLEXES COMPRISING THORIUM RADIONUCLIDE AND HYDROXYPYRIDINONE CONTAINING LIGAND | BAYER AS (NO) | 2020-03-25 | — | — | EP | disclosed |
| EP-3417883-A1 | TARGETED ALPHA-PARTICLE EMITTING COMPLEXES COMPRISING THORIUM RADIONUCLIDE AND HYDROXYPYRIDINONE CONTAINING LIGAND | Bayer AS (NO) | 2018-12-26 | — | — | EP | disclosed |
| EP-2533817-B1 | TARGETED ALPHA-PARTICLE EMITTING COMPLEXES COMPRISING THORIUM RADIONUCLIDE AND HYDROXYPYRIDINONE CONTAINING LIGAND | BAYER AS (NO) | 2018-03-28 | — | — | EP | disclosed |
| US-20170319721-A1 | ALPHA-EMITTING COMPLEXES | BAYER AS (NO) | 2017-11-09 | — | — | US | disclosed |
| US-9724436-B2 | Alpha-emitting complexes | BAYER AS (NO) | 2017-08-08 | — | — | US | disclosed |
| US-9439984-B2 | Macrocycles | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-09-13 | — | — | US | disclosed |
| US-20150157746-A1 | MACROCYCLES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-06-11 | — | — | US | disclosed |
| US-20130183235-A1 | ALPHA-EMITTING COMPLEXES | ALGETA ASA (NO) | 2013-07-18 | — | — | US | disclosed |
| WO-2011098611-A2 | ALPHA-EMITTING COMPLEXES | ALGETA AS (NO) | 2011-08-18 | — | — | WO | disclosed |
| US-5892029-A | HIGHLY EFFECTIVE UPON BOTH INJECTION AND ORAL ADMINISTRATION. | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-04-06 | — | — | US | disclosed |
| EP-0840727-A1 | 3-HYDROXY-2(1H)-PYRIDINONE CHELATING AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-05-13 | — | — | EP | disclosed |
| US-5624901-A | CARBAMOYL SUBSTITUTED COMPOUNDS FOR CHELATE COMPOUNDS FOR MAGNETIC RESONANCE IMAGING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-04-29 | — | — | US | disclosed |
| WO-1997000245-A1 | 3-HYDROXY-2(1H)-PYRIDINONE CHELATING AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130183235-A1 | ALPHA-EMITTING COMPLEXES | TK1, KPNA1, HPRT1 | ALDH1A1 1665/4885TDP1 211/4885L3MBTL1 794/4885 |
| US-10682430-B2 | Alpha-emitting complexes | TK1, KPNA1, HPRT1 | ALDH1A1 1665/4885TDP1 211/4885L3MBTL1 794/4885 |
| US-20170319721-A1 | ALPHA-EMITTING COMPLEXES | TK1, KPNA1, HPRT1 | ALDH1A1 1665/4885TDP1 211/4885L3MBTL1 794/4885 |
| US-20150157746-A1 | MACROCYCLES | SLC39A14, SLC39A3, SLC40A1 | ALDH1A1 3621/4885TDP1 3129/4885L3MBTL1 2812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.