Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C3AR1 | Q16581 | 9/20 | 0.53 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | SUCNR1 | Q9BXA5 | 4/20 | 0.44 |
| ▸ | MMP12 | P39900 | 3/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2247800 | 0.87 | HPGDS (0.52) | C3AR1SLC9A1HPGDSSUCNR1MMP12 | |
| SCHEMBL2245141 | 0.86 | C3AR1 (0.61) | C3AR1SLC9A1SUCNR1CA1 | |
| SCHEMBL3581142 | 0.83 | MMP2 (0.47) | C3AR1MMP12MMP2MMP8MMP13 | |
| SCHEMBL2243866 | 0.81 | C3AR1 (0.67) | C3AR1SLC9A1HPGDSSUCNR1MMP12 | |
| SCHEMBL2246505 | 0.79 | MMP12 (0.64) | HPGDSMMP12MMP2MMP8PTPN1 | |
| SCHEMBL2247335 | 0.78 | C3AR1 (0.46) | C3AR1HPGDSSUCNR1MMP12MMP2 | |
| SCHEMBL2248650 | 0.77 | LMNA (0.56) | HPGDSMMP12MMP2MMP8PTPN1 | |
| SCHEMBL2244822 | 0.76 | KDM4E (0.50) | C3AR1HPGDSMMP12MMP2MMP8 | |
| SCHEMBL23091227 | 0.76 | CYP1A2 (0.59) | C3AR1SLC9A1SUCNR1MMP13 | |
| SCHEMBL2247358 | 0.73 | ADAMTS5 (0.64) | C3AR1SUCNR1MMP12MMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |