Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TOP2A | P11388 | 3/20 | 0.44 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2744582 | 0.87 | KDM4E (0.59) | KDM4EALDH1A1LMNATOP2ATOP2B | |
| SCHEMBL29766836 | 0.87 | KDM4E (0.59) | KDM4EALDH1A1LMNATOP2ATOP2B | |
| SCHEMBL29518174 | 0.86 | MEN1 (0.60) | KDM4EALDH1A1LMNATOP2ATOP2B | |
| SCHEMBL22506561 | 0.86 | HTR3A (0.47) | KDM4EALDH1A1LMNATOP2ATOP2B | |
| Hydrochloric Acid SCHEMBL6004997 | 0.86 | KDM4E (0.57) | KDM4EALDH1A1LMNATOP2ATOP2B | |
| SCHEMBL28458144 | 0.86 | KDM4E (0.57) | KDM4EALDH1A1LMNATOP2ATOP2B | |
| SCHEMBL24616680 | 0.82 | HTR3A (0.47) | KDM4EALDH1A1LMNATOP2ATOP2B | |
| Trifluoroacetic Acid SCHEMBL3808640 | 0.81 | KDM4E (0.53) | KDM4EALDH1A1LMNATOP2ATOP2B | |
| SCHEMBL29766728 | 0.80 | LMNA (0.50) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL10637041 | 0.79 | KDM4E (0.41) | KDM4EALDH1A1LMNATOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020199981-A1 | QUINOLINE CARBOXYLIC ACID ESTER COMPOUND AND PREPARATION METHOD AND USE THEREOF | 山东省联合农药工业有限公司 | 2020-10-08 | — | — | WO | disclosed |