SCHEMBL226337

SCHEMBL226337

O=S(=O)(O)CCN(O)CCS(=O)(=O)O.[NaH].[NaH]

nearest known ligand 0.41

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.41
PDE4A P27815 1/20 0.41
LMNA P02545 1/20 0.41
SLC6A6 P31641 1/20 0.41
CYP2C19 P33261 1/20 0.41
BLM P54132 1/20 0.41
APP P05067 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2889658 1.00 PTGS1 (0.41) PTGS1PDE4ALMNASLC6A6CYP2C19
SCHEMBL7770123 1.00 PTGS1 (0.41) PTGS1PDE4ALMNASLC6A6CYP2C19
SCHEMBL1167764 0.97 PTGS1 (0.43) PTGS1PDE4ALMNASLC6A6CYP2C19
SCHEMBL7904192 0.94 PTGS1 (0.41) PTGS1PDE4ALMNASLC6A6CYP2C19
SCHEMBL8748262 0.85 CA1 (0.39) PTGS1PDE4ALMNASLC6A6CYP2C19
SCHEMBL8042605 0.83 KDM4E (0.37) PTGS1PDE4ALMNASLC6A6CYP2C19
SCHEMBL2321365 0.81 PTGS1 (0.36) PTGS1PDE4ALMNASLC6A6CYP2C19
SCHEMBL14590733 0.80 APP (0.48) PTGS1PDE4ALMNASLC6A6CYP2C19
SCHEMBL19259075 0.79 LMNA (0.36) PTGS1PDE4ALMNASLC6A6CYP2C19
SCHEMBL7997869 0.79

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0682289-B1 Photographic color-developing chemicals in the form of granules KONISHIROKU PHOTO IND (JP) 1999-02-03 EP claimed
US-20230144767-A1 TARGETED NITROXIDE AGENTS UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2023-05-11 US disclosed
US-20210371460-A1 TARGETED NITROXIDE AGENTS UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2021-12-02 US disclosed
US-20200317730-A1 TARGETED NITROXIDE AGENTS UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2020-10-08 US disclosed
US-10751273-B2 Compounds for the treatment of pathologies associated with aging and degenerative disorders University of Pittsburgh—of the Commonwealth System of Higher Education (US) 2020-08-25 US disclosed
US-20190210969-A1 INTRAESOPHAGEAL ADMINISTRATION OF TARGETED NITROXIDE AGENTS FOR PROTECTION AGAINST IONIZING IRRADIATION-INDUCED ESOPHAGITIS UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2019-07-11 US disclosed
US-20180298054-A1 TARGETED NITROXIDE AGENTS University of Pittsburgh - of the Commonwealth Sys tem of Higher Education (US) 2018-10-18 US disclosed
US-9890192-B2 Targeted nitroxide agents University of Pittsburgh—of the Commonwealth System of Higher Education (US) 2018-02-13 US disclosed
US-9732105-B2 Targeted nitroxide agents University of Pittsburgh—of the Commonwealth System of Higher Education (US) 2017-08-15 US disclosed
US-20160151269-A1 COMPOUNDS FOR THE TREATMENT OF PATHOLOGIES ASSOCIATED WITH AGING AND DEGENERATIVE DISORDERS UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2016-06-02 US disclosed
EP-0687950-A1 Granular and tablet-shape processing composition for processing a silver halide photographic light-sensitive material KONICA CORPORATION (JP) 1995-12-20 EP disclosed
EP-0687953-A1 Silver halide photosensitive material automatic developing apparatus KONICA CORPORATION (JP) 1995-12-20 EP disclosed
EP-0682289-A2 Photographic color-developing chemicals in the form of granules KONICA CORPORATION (JP) 1995-11-15 EP disclosed
EP-0678782-A1 Method for manufacturing solid processing composition for silver halide photographic light-sensitive materials KONICA CORPORATION (JP) 1995-10-25 EP disclosed
EP-0678781-A1 Solid processing agent for silver halide photographic light-sensitive materials KONICA CORPORATION (JP) 1995-10-25 EP disclosed
EP-0674219-A1 A method for manufacturing tablet processing agent for silver halide photographic light-sensitive materials KONICA CORPORATION (JP) 1995-09-27 EP disclosed
EP-0668536-A1 Solid developing composition for silver halide photographic light-sensitive materials KONICA CORPORATION (JP) 1995-08-23 EP disclosed
EP-0657778-A1 A method for processing a silver halide color photographic light-sensitive material and producing a color image KONICA CORPORATION (JP) 1995-06-14 EP disclosed
EP-0640872-A2 Solid processing composition for silver halide light-sensitive photographic material and method of processing by the use thereof KONICA CORPORATION (JP) 1995-03-01 EP disclosed
EP-0544319-A1 Silver halide color photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 1993-06-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190210969-A1 INTRAESOPHAGEAL ADMINISTRATION OF TARGETED NITROXIDE AGENTS FOR PROTECTION AGAINST IONIZING IRRADIATION-INDUCED ESOPHAGITIS HSPE1, HSPA9, HSPD1 PTGS1 440/4885PDE4A 4049/4885LMNA 859/4885
US-20160151269-A1 COMPOUNDS FOR THE TREATMENT OF PATHOLOGIES ASSOCIATED WITH AGING AND DEGENERATIVE DISORDERS GLA, AGER, SIRT1 PTGS1 260/4885PDE4A 365/4885LMNA 42/4885
US-20180298054-A1 TARGETED NITROXIDE AGENTS TXNRD2, TXN2, HSPE1 PTGS1 610/4885PDE4A 2628/4885LMNA 1283/4885
US-20200317730-A1 TARGETED NITROXIDE AGENTS TXNRD2, TXN2, HSPE1 PTGS1 610/4885PDE4A 2628/4885LMNA 1283/4885
US-10751273-B2 Compounds for the treatment of pathologies associated with aging and degenerative disorders GLA, AGER, SIRT1 PTGS1 260/4885PDE4A 365/4885LMNA 42/4885
US-20230144767-A1 TARGETED NITROXIDE AGENTS TXNRD2, TXN2, HSPE1 PTGS1 610/4885PDE4A 2628/4885LMNA 1283/4885
US-20210371460-A1 TARGETED NITROXIDE AGENTS TXNRD2, TXN2, HSPE1 PTGS1 610/4885PDE4A 2628/4885LMNA 1283/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.