Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GGT1 | P19440 | 1/20 | 0.39 |
| ▸ | BMP1 | P13497 | 2/20 | 0.35 |
| ▸ | ECE1 | P42892 | 4/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 4/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | CPB1 | P15086 | 1/20 | 0.31 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.30 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.30 |
| ▸ | ITGAL | P20701 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29670111 | 0.83 | GGT1 (0.40) | GGT1ECE1ITGB2ICAM1ITGAL | |
| SCHEMBL18271972 | 0.81 | BMP1 (0.37) | BMP1ECE1MMP2MMP9MMP8 | |
| SCHEMBL4759293 | 0.80 | GGT1 (0.43) | GGT1ECE1CPB2CPB1ITGB2 | |
| SCHEMBL27650327 | 0.79 | GGT1 (0.55) | GGT1ECE1CPB2CPB1ITGB2 | |
| SCHEMBL27650325 | 0.79 | GGT1 (0.55) | GGT1ECE1CPB2CPB1ITGB2 | |
| SCHEMBL25556364 | 0.78 | ECE1 (0.40) | BMP1ECE1MMP2MMP9MMP8 | |
| SCHEMBL8229032 | 0.78 | ECE1 (0.40) | BMP1ECE1MMP2MMP9MMP8 | |
| SCHEMBL8237437 | 0.74 | SIRT6 (0.48) | GGT1CPB2MMP2MMP9MMP1 | |
| SCHEMBL13451427 | 0.73 | GNPAT (0.41) | BMP1ECE1MMP2MMP9MMP8 | |
| SCHEMBL26019602 | 0.73 | GNPAT (0.41) | BMP1ECE1MMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200352887-A1 | HMGB1 ANTAGONIST | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (US) | 2020-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200352887-A1 | HMGB1 ANTAGONIST | HMGB1, HMGB3, HMGB2 | GGT1 1298/4885BMP1 689/4885ECE1 3999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.