Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | KAT8 | Q9H7Z6 | 6/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | EP300 | Q09472 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LOX | P28300 | 1/20 | 0.44 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.44 |
| ▸ | LOXL4 | Q96JB6 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5713339 | 0.83 | LOX (0.63) | POLBHTTLMNAPKMMAPT | |
| SCHEMBL5928736 | 0.81 | MAPT (0.49) | HTTLMNAMAPTALDH1A1KDM4E | |
| SCHEMBL15690146 | 0.81 | LOX (0.69) | POLBHTTLMNAPKMMAPT | |
| SCHEMBL5928770 | 0.76 | MAPT (0.67) | POLBHTTLMNAPKMMAPT | |
| SCHEMBL8663311 | 0.76 | ALDH1A1 (0.76) | POLBHTTLMNAPKMMAPT | |
| SCHEMBL22678453 | 0.75 | MAPT (0.41) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL22670353 | 0.74 | ACSS2 (0.48) | HTTLMNAPKMMAPTALDH1A1 | |
| SCHEMBL5204074 | 0.73 | MAPT (0.52) | POLBHTTLMNAPKMMAPT | |
| SCHEMBL5204078 | 0.73 | MAPT (0.52) | POLBHTTLMNAPKMMAPT | |
| SCHEMBL5206340 | 0.71 | MAPT (0.50) | POLBHTTLMNAPKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020230136-A1 | ACSS2 INHIBITORS AND METHODS OF USE THEREOF | METABOMED LTD (IL) | 2020-11-19 | — | — | WO | disclosed |