Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 9/20 | 0.40 |
| ▸ | FAAH | O00519 | 3/20 | 0.34 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CCR6 | P51684 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2348816 | 0.75 | MGLL (0.53) | HSP90AA1TDP1HTTNPSR1ALDH1A1 | |
| SCHEMBL3414901 | 0.73 | MGLL (0.54) | HSP90AA1TDP1HTTNPSR1ALDH1A1 | |
| SCHEMBL2125273 | 0.71 | ALDH1A1 (0.46) | HSP90AA1TDP1HTTNPSR1ALDH1A1 | |
| SCHEMBL7633213 | 0.65 | MGLL (0.63) | HSP90AA1TDP1HTTNPSR1ALDH1A1 | |
| SCHEMBL8372896 | 0.64 | ALDH1A1 (0.38) | HSP90AA1TDP1HTTNPSR1ALDH1A1 | |
| SCHEMBL19134296 | 0.64 | MGLL (0.67) | HSP90AA1TDP1HTTNPSR1ALDH1A1 | |
| SCHEMBL13749940 | 0.63 | MGLL (0.56) | HSP90AA1TDP1HTTNPSR1ALDH1A1 | |
| SCHEMBL10780780 | 0.62 | MGLL (0.65) | HSP90AA1TDP1HTTNPSR1ALDH1A1 | |
| SCHEMBL11638756 | 0.62 | KMT2A (0.54) | ALDH1A1HPGDMEN1KMT2AHTR1A | |
| SCHEMBL28308627 | 0.62 | MGLL (0.59) | HSP90AA1TDP1HTTNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003078-B2 | Targeted MR imaging agents | BARNES-JEWISH HOSPITAL (US) | 2011-08-23 | — | — | US | disclosed |
| US-20080247943-A1 | Blood Clot-Targeted Nanoparticles | KEREOS, INC. | 2008-10-09 | — | — | US | disclosed |
| EP-1539252-A4 | BLOOD CLOT-TARGETED NANOPARTICLES | BARNES JEWISH HOSPITAL (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007115115-A2 | TARGETED MR IMAGING AGENTS | KEREOS, INC. (US) | 2007-10-11 | — | — | WO | disclosed |
| US-20070237721-A1 | TARGETED MR IMAGING AGENTS | KEREOS, INC. | 2007-10-11 | — | — | US | disclosed |
| US-20070202040-A1 | Blood clot-targeted nanoparticles | BARNES-JEWISH HOSPITAL (US) | 2007-08-30 | — | — | US | disclosed |
| EP-1539252-A2 | BLOOD CLOT-TARGETED NANOPARTICLES | Barnes-Jewish Hospital (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004017907-A2 | BLOOD CLOT-TARGETED NANOPARTICLES | BARNES-JEWISH HOSPITAL (US) | 2004-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080247943-A1 | Blood Clot-Targeted Nanoparticles | FGB, PLAT, PLG | HSP90AA1 1089/4885TDP1 626/4885HTT 665/4885 |
| US-20070237721-A1 | TARGETED MR IMAGING AGENTS | TSPO, ARNT, RXFP4 | HSP90AA1 1548/4885TDP1 4051/4885HTT 780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.