SCHEMBL2268690

SCHEMBL2268690

CCCC[SiH](NC)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.35
DNM1 Q05193 2/20 0.34
HTT P42858 3/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
NPSR1 Q6W5P4 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
TP53 P04637 1/20 0.33
MAPK1 P28482 1/20 0.33
PCSK9 Q8NBP7 1/20 0.33
GAA P10253 1/20 0.33
MAPT P10636 1/20 0.33
ALOX12 P18054 1/20 0.33
CRHBP P24387 1/20 0.33
CRHR2 Q13324 1/20 0.33
LTA4H P09960 1/20 0.33
ALDH1A1 P00352 3/20 0.33
TSHR P16473 1/20 0.33
NAAA Q02083 1/20 0.33
PTGS2 P35354 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2267562 0.88 LMNA (0.33) TP53MAPTTSHRPTGS2
SCHEMBL2268688 0.82 SIGMAR1 (0.34) SIGMAR1HTTNPSR1SMN1; SMN2PCSK9
SCHEMBL2267927 0.79 LMNA (0.35) SIGMAR1TP53MAPTTSHR
SCHEMBL2101844 0.75 CACNA2D1 (0.37) SIGMAR1
SCHEMBL417994 0.74 LTA4H (0.38) SIGMAR1DNM1NPSR1SMN1; SMN2TP53
SCHEMBL114779 0.74 LTA4H (0.38) SIGMAR1DNM1MEN1KMT2ASMN1; SMN2
SCHEMBL27967013 0.72 LMNA (0.34) SIGMAR1SMN1; SMN2MAPTTSHR
SCHEMBL7815018 0.72 LTA4H (0.36) SIGMAR1DNM1HTTMEN1KMT2A
SCHEMBL3482045 0.71 PCSK9 (0.39) HTTNPSR1SMN1; SMN2PCSK9GAA
SCHEMBL704628 0.71 LTA4H (0.35) SIGMAR1DNM1HTTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8404584-B2 Method of manufacturing semiconductor device FUJITSU LIMITED (JP) 2013-03-26 US disclosed
US-20110207319-A1 METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE FUJITSU LIMITED (JP) 2011-08-25 US disclosed