SCHEMBL2269324

SCHEMBL2269324

Cc1ccccc1-c1ccc(C(=O)OC(C)(C)C)c(NC(=O)c2ccccc2)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.47
HPGD P15428 1/20 0.47
NR1H4 Q96RI1 2/20 0.46
KDM4E B2RXH2 1/20 0.44
MAPK1 P28482 1/20 0.44
HSD17B10 Q99714 1/20 0.44
HDAC1 Q13547 4/20 0.44
FFAR1 O14842 1/20 0.43
MEN1 O00255 3/20 0.43
MAPT P10636 3/20 0.43
KMT2A Q03164 3/20 0.43
PKM P14618 1/20 0.43
GRIK1 P39086 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
HDAC2 Q92769 4/20 0.42
MCL1 Q07820 1/20 0.42
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
HDAC3 O15379 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2274794 0.88 RAB9A (0.44) HPGDKDM4EMAPK1HSD17B10HDAC1
SCHEMBL12118094 0.87 CCNC (0.45) POLBNR1H4MAPK1HSD17B10HDAC1
SCHEMBL2268169 0.84 HDAC1 (0.47) POLBHPGDKDM4EMAPK1HSD17B10
SCHEMBL2270787 0.84 MEN1 (0.57) POLBHPGDNR1H4HDAC1FFAR1
SCHEMBL2274754 0.84 HDAC2 (0.53) KDM4EMAPK1HSD17B10HDAC1MEN1
SCHEMBL2273488 0.82 SUCNR1 (0.52) HDAC1MEN1KMT2AHDAC2HDAC3
SCHEMBL2269847 0.82 HDAC2 (0.52) NR1H4KDM4EMAPK1HSD17B10HDAC1
Cyanate SCHEMBL27830146 0.82 HDAC2 (0.51) KDM4EMAPK1HSD17B10HDAC1HDAC2
SCHEMBL27989086 0.81 HDAC1 (0.56) HDAC1HDAC2HDAC3
SCHEMBL2275605 0.81 ACLY (0.53) HPGDNR1H4KDM4EHDAC1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 POLB 3860/4885HPGD 274/4885NR1H4 2482/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.