SCHEMBL2270154

SCHEMBL2270154

COc1ccccc1C(=O)Nc1cc(Oc2ccccc2)ccc1C(=O)O

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.65
▸ MEN1 O00255 2/20 0.65
▸ RAB9A P51151 2/20 0.64
▸ AKR1C3 P42330 1/20 0.56
▸ AKR1C2 P52895 1/20 0.56
▸ PYGM P11217 1/20 0.55
▸ MAPT P10636 2/20 0.54
▸ TSHR P16473 2/20 0.54
▸ HSD17B10 Q99714 2/20 0.54
▸ GAA P10253 1/20 0.54
▸ MAPK1 P28482 1/20 0.54
▸ LMNA P02545 2/20 0.54
▸ KDM4E B2RXH2 2/20 0.54
▸ HPGD P15428 1/20 0.54
▸ ATM Q13315 1/20 0.54
▸ NPSR1 Q6W5P4 1/20 0.54
▸ KCNMA1 Q12791 1/20 0.53
▸ PYGL P06737 1/20 0.53
▸ CYP2C9 P11712 1/20 0.53
▸ CYP2C19 P33261 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2291839 0.90 KMT2A (0.65) KMT2AMEN1RAB9APYGMMAPT
SCHEMBL2271662 0.86 KMT2A (0.57) KMT2AMEN1RAB9AMAPTTSHR
SCHEMBL2268019 0.85 MAPK1 (0.57) KMT2AMEN1RAB9AGAAMAPK1
SCHEMBL12912325 0.84 KCNMA1 (0.73) KMT2AMEN1RAB9AMAPTTSHR
SCHEMBL7129418 0.84 PYGL (0.74) KMT2AMEN1RAB9APYGMMAPT
SCHEMBL2271007 0.84 MEN1 (0.69) KMT2AMEN1AKR1C3AKR1C2PYGM
SCHEMBL11789635 0.83 KCNK3 (0.68) KMT2AMEN1RAB9AMAPTTSHR
SCHEMBL2274195 0.83 PNLIP (0.66) KMT2AMEN1RAB9AMAPTGAA
SCHEMBL27848838 0.82 KMT2A (0.77) KMT2AMEN1RAB9AMAPTTSHR
SCHEMBL2272706 0.82 MEN1 (0.67) KMT2AMEN1RAB9AAKR1C3AKR1C2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 — — US disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 — — US disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 — — US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 — — US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 — — US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 — — US disclosed
CN-101094829-A Novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD (JP) 2007-12-26 — — CN disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 KMT2A 1669/4885MEN1 3105/4885RAB9A 2238/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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